IMPROVEMENT OF NEUROLOGICAL FUNCTION IN RATS WITH ISCHEMIC STROKE BY ADIPOSEDERIVED PERICYTES

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dc.contributor.authorOgay, Vyacheslav
dc.contributor.authorKumasheva, Venera
dc.contributor.authorLi, Yelena
dc.contributor.authorMukhlis, Sholpan
dc.contributor.authorSekenova, Aliya
dc.contributor.authorOlzhayev, Farkhad
dc.contributor.authorTsoy, Andrey
dc.contributor.authorUmbayev, Baurzhan
dc.contributor.authorAskarova, Sholpan
dc.contributor.authorShpekov, Azat
dc.contributor.authorKaliyev, Assylbek
dc.contributor.authorZhetpisbayev, Berik
dc.contributor.authorMakhambetov, Yerbol
dc.contributor.authorAkshulakov, Serik
dc.contributor.authorSaparov, Arman
dc.contributor.authorRamankulov, Yerlan
dc.date.accessioned2021-07-02T08:37:49Z
dc.date.available2021-07-02T08:37:49Z
dc.date.issued2020-09-04
dc.description.abstractPericytes possess high multipotent features and cell plasticity, and produce angiogenic and neurotrophic factors that indicate their high regenerative potential. The aim of this study was to investigate whether transplantation of adipose-derived pericytes can improve functional recovery and neurovascular plasticity after ischemic stroke in rats. Rat adipose-derived pericytes were isolated from subcutaneous adipose tissue by fluorescence-activated cell sorting. Adult male Wistar rats were subjected to 90 min of middle cerebral artery occlusion followed by intravenous injection of rat adipose-derived pericytes 24 h later. Functional recovery evaluations were performed at 1, 7, 14, and 28 days after injection of rat adipose-derived pericytes. Angiogenesis and neurogenesis were examined in rat brains using immunohistochemistry. It was observed that intravenous injection of adipose-derived pericytes significantly improved recovery of neurological function in rats with stroke compared to phosphate-buffered saline– treated controls. Immunohistochemical analysis revealed that the number of blood capillaries was significantly increased along the ischemic boundary zone of the cortex and striatum in stroke rats treated with adipose-derived pericytes. In addition, treatment with adipose-derived pericytes increased the number of doublecortin positive neuroblasts. Our data suggest that transplantation of adipose-derived pericytes can significantly improve the neurologic status and contribute to neurovascular remodeling in rats after ischemic stroke. These data provide a new insight for future cell therapies that aim to treat ischemic stroke patients.en_US
dc.identifier.citationOgay, V., Kumasheva, V., Li, Y., Mukhlis, S., Sekenova, A., Olzhayev, F., Tsoy, A., Umbayev, B., Askarova, S., Shpekov, A., Kaliyev, A., Zhetpisbayev, B., Makhambetov, Y., Akshulakov, S., Saparov, A., & Ramankulov, Y. (2020). Improvement of Neurological Function in Rats with Ischemic Stroke by Adipose-derived Pericytes. Cell Transplantation, 29, 096368972095695. https://doi.org/10.1177/0963689720956956en_US
dc.identifier.issn0963-6897
dc.identifier.urihttps://doi.org/10.1177/0963689720956956
dc.identifier.urihttps://journals.sagepub.com/doi/10.1177/0963689720956956
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/5517
dc.language.isoenen_US
dc.publisherSAGE Publicationsen_US
dc.relation.ispartofseriesCell Transplantation;Volume 29: 1–12
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectpericytesen_US
dc.subjectneurogenesisen_US
dc.subjectangiogenesisen_US
dc.subjectneurological recoveryen_US
dc.subjectischemic strokeen_US
dc.subjectType of access: Open Accessen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleIMPROVEMENT OF NEUROLOGICAL FUNCTION IN RATS WITH ISCHEMIC STROKE BY ADIPOSEDERIVED PERICYTESen_US
dc.typeArticleen_US
workflow.import.sourcescience

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