THE POTENTIAL ROLE OF EXTRACELLULAR VESICLES IN COVID-19 TREATMENT: OPPORTUNITY AND CHALLENGE

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Date

2021-07-21

Authors

Yan, Yan-yan
Zhou, Wen-min
Wang, Yu-qing
Guo, Qiao-ru
Zhao, Fu-xi
Zhu, Zhuang-yan
Xing, Yan-xia
Zhang, Hai-yan
Aljofan, Mohamad
Jarrahi, Alireza Mosavi

Journal Title

Journal ISSN

Volume Title

Publisher

Frontiers Media S.A.

Abstract

SARS-CoV-2 infection has become an urgent public health concern worldwide, severely affecting our society and economy due to the long incubation time and high prevalence. People spare no effort on the rapid development of vaccine and treatment all over the world. Amongst the numerous ways of tackling this pandemic, some approaches using extracellular vesicles (EVs) are emerging. In this review, we summarize current prevalence and pathogenesis of COVID-19, involving the combination of SARS-CoV-2 and virus receptor ACE2, endothelial dysfunction and micro thrombosis, together with cytokine storm. We also discuss the ongoing EVs-based strategies for the treatment of COVID-19, including mesenchymal stem cell (MSC)-EVs, drug-EVs, vaccine-EVs, platelet-EVs, and others. This manuscript provides the foundation for the development of targeted drugs and vaccines for SARS-CoV-2 infections.

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Keywords

Type of access: Open Access, ACE2, COVID-19, extracellular vesicles (EVs), immunomodulation, mesenchymal stem cell (MSC), SARS-CoV-2

Citation

Yan, Y., Zhou, W., Wang, Y., Guo, Q., Zhao, F., Zhu, Z., Xing, Y., Zhang, H., Aljofan, M., Jarrahi, A. M., Makabel, B., & Zhang, J. (2021). The Potential Role of Extracellular Vesicles in COVID-19 Treatment: Opportunity and Challenge. In Frontiers in Molecular Biosciences (Vol. 8). Frontiers Media SA. https://doi.org/10.3389/fmolb.2021.699929

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