Mesenchymal stem cells modifications for enhanced bone targeting and bone regeneration

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dc.contributor.authorSafarova, Yuliya
dc.contributor.authorUmbayev, Bauyrzhan
dc.contributor.authorHortelano, Gonzalo
dc.contributor.authorAskarova, Sholpan
dc.date.accessioned2020-08-21T05:46:37Z
dc.date.available2020-08-21T05:46:37Z
dc.date.issued2020-04-16
dc.description.abstractIn pathological bone conditions (e.g., osteoporotic fractures or critical size bone defects), increasing the pool of osteoblast progenitor cells is a promising therapeutic approach to facilitate bone healing. Since mesenchymal stem cells (MSCs) give rise to the osteogenic lineage, a number of clinical trials investigated the potential of MSCs transplantation for bone regeneration. However, the engraftment of transplanted cells is often hindered by insufficient oxygen and nutrients supply and the tendency of MSCs to home to different sites of the body. In this review, we discuss various approaches of MSCs transplantation for bone regeneration including scaffold and hydrogel constructs, genetic modifications and surface engineering of the cell membrane aimed to improve homing and increase cell viability, proliferation and differentiation.en_US
dc.identifier.citationSafarova, Y., Umbayev, B., Hortelano, G., & Askarova, S. (2020). Mesenchymal stem cells modifications for enhanced bone targeting and bone regeneration. Regenerative Medicine, 15(4), 1579–1594. https://doi.org/10.2217/rme-2019-0081en_US
dc.identifier.issn1746-0751
dc.identifier.issn1746-076X
dc.identifier.urihttps://www.futuremedicine.com/doi/10.2217/rme-2019-0081
dc.identifier.urihttps://doi.org/10.2217/rme-2019-0081
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/4924
dc.language.isoenen_US
dc.publisherFuture Medicineen_US
dc.relation.ispartofseriesRegenerative Medicine;
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectbone regenerationen_US
dc.subjectcell surface engineeringen_US
dc.subjectgenetic modificationsen_US
dc.subjecthydrogelsen_US
dc.subjectMSCsen_US
dc.subjectscaffoldsen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleMesenchymal stem cells modifications for enhanced bone targeting and bone regenerationen_US
dc.typeArticleen_US
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