Functionalized Magnetic Force Enhances Magnetic Nanoparticle Guidance: From Simulation to Crossing of the Blood-Brain Barrier in vivo

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dc.contributor.authorDo, Ton Duc
dc.contributor.authorAmin, Faiz Ul
dc.contributor.authorNoh, Yeongil
dc.contributor.authorKim, Myeong Ok
dc.contributor.authorYoon, Jungwon
dc.date.accessioned2016-02-08T07:47:46Z
dc.date.available2016-02-08T07:47:46Z
dc.date.issued2016
dc.description.abstractIn recent studies, we introduced the concept of functionalized magnetic force as a method to prevent nanoparticles from sticking to vessel walls caused by extensive simulation and in vitro experiments involving a Y-shaped channel. In this study, we further investigated the effectiveness of the functionalized magnetic force with a realistic 3D vessel through simulations. For the simulations, we considered a more realistic continuous injection of particles with different magnetic forces and frequencies. Based on the results from our simulation studies, we performed in vivo mice experiments to evaluate the effectiveness of using a functionalized magnetic force to aid magnetic nanoparticles (MNPs) in crossing the blood-brain barrier (BBB). To implement the functionalized magnetic force, we developed an electromagnetic actuator regulated by a programmable direct current (DC) power supply. Our results indicate that a functionalized magnetic field can effectively prevent MNPs from sticking, and also guide them across the BBB. We used 770-nm fluorescent carboxyl MNPs in this study. Following intravenous administration of MNPs into mice, we applied an external magnetic field (EMF) to mediate transport of the MNPs across the BBB and into the brain. Furthermore, we evaluated the differential effects of functionalized magnetic fields (0.25, 0.5, and 1 Hz) and constant magnetic fields on the transport of MNPs across the BBB. Our results showed that a functionalized magnetic field is more effective than a constant magnetic field in the transport and uptake of MNPs across the BBB in mice. Specifically, applying a functionalized magnetic field with a 3 A current and 0.5 Hz frequency mediated the greatest transport and uptake of MNPs across the BBB in miceru_RU
dc.identifier.citationTon Duc Do, Faiz Ul Amin, Yeongil Noh, Myeong Ok Kim, Jungwon Yoon; 2015; Functionalized Magnetic Force Enhances Magnetic Nanoparticle Guidance: From Simulation to Crossing of the Blood-Brain Barrier in vivo; IEEE Transactions on Magneticsru_RU
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/1182
dc.language.isoenru_RU
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectBlood-brain barrierru_RU
dc.subjectIn vivo experimentru_RU
dc.subjectMiceru_RU
dc.subjectTargeted drug deliveryru_RU
dc.subjectElectromagnetic actuation systemru_RU
dc.subjectSimulationru_RU
dc.titleFunctionalized Magnetic Force Enhances Magnetic Nanoparticle Guidance: From Simulation to Crossing of the Blood-Brain Barrier in vivoru_RU
dc.typeArticleru_RU

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