Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation

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dc.contributor.authorSun, Xiaoming
dc.contributor.authorShi, Yi
dc.contributor.authorAkahoshi, Tomohiro
dc.contributor.authorFujiwara, Mamoru
dc.contributor.authorGatanaga, Hiroyuki
dc.contributor.authorSchönbach, Christian
dc.contributor.authorKuse, Nozomi
dc.contributor.authorAppay, Victor
dc.contributor.authorGao, George F.
dc.contributor.authorOka, Shinichi
dc.contributor.authorTakiguchi, Masafumi
dc.creatorXiaoming, Sun
dc.date.accessioned2018-01-05T03:54:52Z
dc.date.available2018-01-05T03:54:52Z
dc.date.issued2016-06-07
dc.description.abstractSummary The mechanistic basis for the progressive accumulation of Y135F Nef mutant viruses in the HIV-1-infected population remains poorly understood. Y135F viruses carry the 2F mutation within RW8 and RF10, which are two HLA-A∗24:02-restricted superimposed Nef epitopes recognized by distinct and adaptable CD8+ T cell responses. We combined comprehensive analysis of the T cell receptor repertoire and cross-reactive potential of wild-type or 2F RW8- and RF10-specific CD8+ T cells with peptide-MHC complex stability and crystal structure studies. We find that, by affecting direct and water-mediated hydrogen bond networks within the peptide-MHC complex, the 2F mutation reduces both TCR and HLA binding. This suggests an advantage underlying the evolution of the 2F variant with decreased CD8+ T cell efficacy. Our study provides a refined understanding of HIV-1 and CD8+ T cell co-adaptation at the population level.en_US
dc.identifierDOI:10.1016/j.celrep.2016.05.017
dc.identifier.citationXiaoming Sun, Yi Shi, Tomohiro Akahoshi, Mamoru Fujiwara, Hiroyuki Gatanaga, Christian Schönbach, Nozomi Kuse, Victor Appay, George F. Gao, Shinichi Oka, Masafumi Takiguchi, Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation, In Cell Reports, Volume 15, Issue 10, 2016, Pages 2279-2291en_US
dc.identifier.issn22111247
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S221112471630585X
dc.identifier.urihttp://nur.nu.edu.kz/handle/123456789/3113
dc.language.isoenen_US
dc.publisherCell Reportsen_US
dc.relation.ispartofCell Reports
dc.rights.license© 2016 The Authors.
dc.titleEffects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptationen_US
dc.typeArticleen_US
elsevier.aggregationtypeJournal
elsevier.coverdate2016-06-07
elsevier.coverdisplaydate7 June 2016
elsevier.endingpage2291
elsevier.identifier.doi10.1016/j.celrep.2016.05.017
elsevier.identifier.eid1-s2.0-S221112471630585X
elsevier.identifier.piiS2211-1247(16)30585-X
elsevier.identifier.pubmedid27239036
elsevier.identifier.scopusid84969850541
elsevier.issue.identifier10
elsevier.openaccess1
elsevier.openaccessarticletrue
elsevier.openaccessuserlicensehttp://creativecommons.org/licenses/by-nc-nd/4.0/
elsevier.openarchivearticlefalse
elsevier.startingpage2279
elsevier.teaserRational design of T cell vaccines requires understanding of T cell and HIV-1 co-evolution. Sun et al. find that a single immune escape mutation has differential impacts on two HIV epitope-specific responses. The mutation alters the ability of the virus to trigger immune responses.
elsevier.volume15
workflow.import.sourcescience

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