RETROSPECTIVE ANALYSIS OF DELAYED GRAFT FUNCTION INCIDENCE IN KIDNEY TRANSPLANT IN KAZAKHSTAN

Abstract

The incidence of delayed graft function (DGF) poses a considerable challenge, impacting both graft and patient survival. The objective of this paper was to investigate the incidence of DGF and factors that contribute to its manifestation in a group of 115 kidney transplant recipients in Kazakhstan. A multivariate logistic regression showed that the overall incidence of DGF was found to be 13.91%, with deceased donor kidney recipients exhibiting a higher rate (41.17%) as opposed to living donor recipients (9.28%). Moreover, analysis disclosed a marginally significant relationship between the age of the recipient and DGF risk (OR: 1.08, 95% CI: 0.99-1.19, p = 0.090). Additionally, a statistically significant correlation between obtaining an organ from a deceased donor and an elevated risk of DGF (OR:69.28301, 95% CI: 4.48-1071.76 a p = 0.002), was established. The relationship between HLA mismatch and DGF risk was found to be of borderline statistical significance (OR: 0.96, 95% CI: 0.92-1.00, p = 0.052). No meaningful association between gender and DGF risk was detected. The findings underscore the significance of donor type concerning DGF risk and propose potential links between recipient age and HLA mismatch.