Abstract:
Sweat is a colourless liquid excreted in the skin that contains mostly water. The presence
of endogenous and exogenous substances in sweat permits feasible analysis of biomarkers
of most cancers. Integrating the information of those substances as a panel of biomarkers
it is possible to design precise biosensors. The biosensor will allow a self-check-up device
that is non-invasive, wearable, rapid and flexible. By preparing artificial control sweat
and artificial biomarkers containing sweat solutions, as well as analysis of their refractive
index (RI), improvement of the biosensor is possible. The analysis of the sensitivity
of the semi-distributed interferometer and titled fiber Bragg grating is done in order to
identify the most promising biosensor. By analysing sensors’ activity during RI changes,
biomarkers concentration changes, and temperature changes, the semi-distributed sensor
was chosen. It exhibited a higher correlation with the changes and showed more reliable
graphics due to a high R2 value.