Abstract:
The data regarding the role of progesterone (P4) in reproductive events of endometriosis
patients are limited. This prospective study aimed to examine the predictive value of basal P4 serum
levels for successful in vitro fertilization (IVF) in patients with primary infertility and endometriosis.
The study included 73 patients divided according to endometriosis treatment (surgery vs. control—no
treatment). The general data, basal hormonal status, and pregnancy rates were determined for every
patient. Clinical pregnancy was achieved in 40.3% of patients, and more often in patients treated for
endometriosis before IVF. The regression analysis showed that higher basal P4 serum levels were
associated with achieving pregnancy through IVF. When regression was adjusted for the patient and
IVF characteristics, higher basal P4 serum levels were associated with pregnancy achievement in
both groups of women, along with the basal serum levels of FSH, LH, and AMH; EFI score; and
stimulation protocol. The ROC analysis showed that the basal P4 serum level for successful IVF
should be 0.7ng/mL. The basal P4 serum level cut-off for IVF success in endometriosis patients
was determined for the first time. Constructed models for IVF success prediction emphasize the
importance of determining the basal P4 serum levels for the personalized treatment of endometriosisrelated
infertility.