dc.contributor.author | Singh, Prim B. | |
dc.contributor.author | Newman, Andrew G. | |
dc.date.accessioned | 2022-11-24T04:46:16Z | |
dc.date.available | 2022-11-24T04:46:16Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Singh, P. B., & Newman, A. G. (2022). HP1-Driven Micro-Phase Separation of Heterochromatin-Like Domains/Complexes. Epigenetics Insights, 15, 251686572211097. https://doi.org/10.1177/25168657221109766 | en_US |
dc.identifier.uri | http://nur.nu.edu.kz/handle/123456789/6826 | |
dc.description.abstract | Cytologically visible constitutive heterochromatin found at the centromeric and telomeric regions of chromosomes represents the largest differentiated chromatin compartment in eukaryotic nuclei.1 Outside constitutive heterochromatin, heterochromatin- like domains (HLD, >.1 Mb) and complexes (HLC, <.1 Mb) are found along the chromosome arms.2 HLD/Cs are present in eukaryotic genomes as divergent as fission yeast and human, with expansions in size and number in mammals. In human, there are ~163 to 859 HLDs and ~18 853 to 32 292 HLCs, depending on cell type.2 Some of the largest HLDs are the KRAB-ZNF HLDs on chromosome 19. Notably, contacts among these large HLDs emerge as the heterochromatic B4 sub-compartment in Hi-C maps... | en_US |
dc.language.iso | en | en_US |
dc.publisher | Epigenetics Insights | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/us/ | * |
dc.subject | Type of access: Open Access | en_US |
dc.subject | Heterochromatin | en_US |
dc.subject | HP1 | en_US |
dc.subject | Hi-C | en_US |
dc.subject | H3K9me3 | en_US |
dc.subject | phase separation | en_US |
dc.title | HP1-DRIVEN MICRO-PHASE SEPARATION OF HETEROCHROMATIN-LIKE DOMAINS/COMPLEXES | en_US |
dc.type | Article | en_US |
workflow.import.source | science |
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