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HP1-DRIVEN MICRO-PHASE SEPARATION OF HETEROCHROMATIN-LIKE DOMAINS/COMPLEXES

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dc.contributor.author Singh, Prim B.
dc.contributor.author Newman, Andrew G.
dc.date.accessioned 2022-11-24T04:46:16Z
dc.date.available 2022-11-24T04:46:16Z
dc.date.issued 2022
dc.identifier.citation Singh, P. B., & Newman, A. G. (2022). HP1-Driven Micro-Phase Separation of Heterochromatin-Like Domains/Complexes. Epigenetics Insights, 15, 251686572211097. https://doi.org/10.1177/25168657221109766 en_US
dc.identifier.uri http://nur.nu.edu.kz/handle/123456789/6826
dc.description.abstract Cytologically visible constitutive heterochromatin found at the centromeric and telomeric regions of chromosomes represents the largest differentiated chromatin compartment in eukaryotic nuclei.1 Outside constitutive heterochromatin, heterochromatin- like domains (HLD, >.1 Mb) and complexes (HLC, <.1 Mb) are found along the chromosome arms.2 HLD/Cs are present in eukaryotic genomes as divergent as fission yeast and human, with expansions in size and number in mammals. In human, there are ~163 to 859 HLDs and ~18 853 to 32 292 HLCs, depending on cell type.2 Some of the largest HLDs are the KRAB-ZNF HLDs on chromosome 19. Notably, contacts among these large HLDs emerge as the heterochromatic B4 sub-compartment in Hi-C maps... en_US
dc.language.iso en en_US
dc.publisher Epigenetics Insights  en_US
dc.rights Attribution-NonCommercial-ShareAlike 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/us/ *
dc.subject Type of access: Open Access en_US
dc.subject Heterochromatin en_US
dc.subject HP1 en_US
dc.subject Hi-C en_US
dc.subject H3K9me3 en_US
dc.subject phase separation en_US
dc.title HP1-DRIVEN MICRO-PHASE SEPARATION OF HETEROCHROMATIN-LIKE DOMAINS/COMPLEXES en_US
dc.type Article en_US
workflow.import.source science


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