STUDY OF GUT MICROBIOTA ALTERATIONS IN ALZHEIMER’S DEMENTIA PATIENTS FROM KAZAKHSTAN
Loading...
Date
2022
Authors
Kaiyrlykyzy, Aiym
Kozhakhmetov, Samat
Babenko, Dmitriy
Zholdasbekova, Gulnaz
Alzhanova, Dinara
Olzhayev, Farkhad
Baibulatova, Aida
Kushugulova, Almagul R.
Askarova, Sholpan
Journal Title
Journal ISSN
Volume Title
Publisher
Scientific Reports
Abstract
We have investigated the diversity and composition of gut microbiotas isolated from AD (Alzheimer’s
disease) patients (n = 41) and healthy seniors (n = 43) from Nur-Sultan city (Kazakhstan). The
composition of the gut microbiota was characterized by 16S ribosomal RNA sequencing. Our
results demonstrated significant differences in bacterial abundance at phylum, class, order,
and genus levels in AD patients compared to healthy aged individuals. Relative abundance
analysis has revealed increased amount of taxa belonging to Acidobacteriota, Verrucomicrobiota,
Planctomycetota and Synergistota phyla in AD patients. Among bacterial genera, microbiotas
of AD participants were characterized by a decreased amount of Bifidobacterium, Clostridia
bacterium, Castellaniella, Erysipelotrichaceae UCG-003, Roseburia, Tuzzerella, Lactobacillaceae and
Monoglobus. Differential abundance analysis determined enriched genera of Christensenellaceae
R-7 group, Prevotella, Alloprevotella, Eubacterium coprostanoligenes group, Ruminococcus,
Flavobacterium, Ohtaekwangia, Akkermansia, Bacteroides sp. Marseille-P3166 in AD patients, whereas
Levilactobacillus, Lactiplantibacillus, Tyzzerella, Eubacterium siraeum group, Monoglobus, Bacteroides,
Erysipelotrichaceae UCG-003, Veillonella, Faecalibacterium, Roseburia, Haemophilus were depleted. We
have also found correlations between some bacteria taxa and blood serum biochemical parameters.
Adiponectin was correlated with Acidimicrobiia, Faecalibacterium, Actinobacteria, Oscillospiraceae,
Prevotella and Christensenellaceae R-7. The Christensenellaceae R-7 group and Acidobacteriota were
correlated with total bilirubin, while Firmicutes, Acidobacteriales bacterium, Castellaniella alcaligenes,
Lachnospiraceae, Christensenellaceae and Klebsiella pneumoniae were correlated with the level of CRP
in the blood of AD patients. In addition, we report the correlations found between disease severity and
certain fecal bacteria. This is the first reported study demonstrating gut microbiota alterations in AD in
the Central Asian region.
Description
Keywords
Type of access: Open Access, ALZHEIMER’S DISEASE, microbiota, patients, dementia, Kazakhstan
Citation
Kaiyrlykyzy, A., Kozhakhmetov, S., Babenko, D., Zholdasbekova, G., Alzhanova, D., Olzhayev, F., Baibulatova, A., Kushugulova, A. R., & Askarova, S. (2022). Study of gut microbiota alterations in Alzheimer’s dementia patients from Kazakhstan. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-19393-0