Abstract:
Radiofrequency ablation is one of the thermal ablation methods that is an alternative
approach to cancer treatment. Currently, it is a widely used method in medicine with adverse
consequences as it injures healthy tissue around the tumor. Gold nanoparticles are represented as
a promised material in biomedical engineering to apply in thermal ablation treatment. This
master thesis aims to evaluate the different densities of gold nanoparticles on the temperature
distribution during radiofrequency ablation of parenchymal tissue in repeated experiments. In
addition, agarose gel and pristine tissue were also analyzed to compare results in the point of
temperature change tendency. Gold nanoparticles diluted with agarose in different volumes
impact the treated area in different ways. Hence, the density directly affects the distribution of
heat on the phantom and assists to avoid healthy cells death. As a sensing system, magnesium
oxide nanoparticle-based high-scattered six fibers and optical backscatter reflectometer LUNA
4600 was used to measure the heating area and analyze the received data. All results are
represented as thermal maps to evaluate a heating area diameter and repeatability similarity in
four different cases.