EFFECT OF GRAPHENE OXIDE/HYDROXYAPATITE NANOCOMPOSITE ON OSTEOGENIC DIFFERENTIATION AND ANTIMICROBIAL ACTIVITY
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Date
2021
Authors
Daulbayev, Chingis
Sultanov, Fail
Korobeinyk, Alina V.
Yeleuov, Mukhtar
Taurbekov, Azamat
Bakbolat, Baglan
Umirzakov, Arman
Baimenov, Alzhan
Journal Title
Journal ISSN
Volume Title
Publisher
Surfaces and Interfaces
Abstract
This paper presents the fabrication and characterization of electrospun graphene oxide/calcium hydroxyapatite/polycaprolactone composite. Polycaprolactone is well-known for its excellent medical property and chemo-resistance. On the other hand graphene oxide (GO) and calcium hydroxyapatite (HAp) are both known for their superior biocompatibility, high mechanical properties, considerable electrical and thermal conductivity. Under current research GO and HAp were synthesized from an abundant bio-wastes material. As-prepared GO/HAp composite was dispersed in biodegradable polymer – polycaprolactone (PCL) in order to device a composite scaffold with the purpose to enhance osteogenic differentiation of osteoblasts for potential medical application. Synthesised composite was characterised using various chemo-physical methods. Biocompatibility was tested in the cell proliferation assay with preosteoblasts MC3T3-E1 cell line in order to identify any cytotoxic effect caused by its compounds. The bacteriostatic effect of GO was assessed using Staphylococcus aureus and Escherichia coli bacterial strains. Obtained GO/HAp/PCL composite scaffold can serve as a biologically compatible matrix for potential bone tissue regeneration with antimicrobial effect; provides an excellent biological compatibility for prospective application in medicine and clinical dentistry.
Description
Keywords
Type of access: Open Access, Graphene oxide, Hydroxyapatite, Electrospinning, Antimicrobial activity, Osteogenic differentiation
Citation
Daulbayev, C., Sultanov, F., Korobeinyk, A. V., Yeleuov, M., Taurbekov, A., Bakbolat, B., Umirzakov, A., Baimenov, A., & Daulbayev, O. (2022). Effect of graphene oxide/hydroxyapatite nanocomposite on osteogenic differentiation and antimicrobial activity. Surfaces and Interfaces, 28, 101683. https://doi.org/10.1016/j.surfin.2021.101683