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Development of an optical biosensor for diagnosis of tuberculosis

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dc.contributor.author Kanayeva, D.
dc.contributor.author Bekmurzayeva, A.
dc.contributor.author Bekniyazov, I.
dc.contributor.author Rakhmetova, A.
dc.contributor.author Sypabekova, M.
dc.contributor.author Ashikbayeva, Z.
dc.contributor.author Akan, M.
dc.contributor.author Wang, R.
dc.contributor.author Lum, J.
dc.contributor.author Li, Y.
dc.date.accessioned 2015-10-28T08:57:50Z
dc.date.available 2015-10-28T08:57:50Z
dc.date.issued 2013
dc.identifier.uri http://nur.nu.edu.kz/handle/123456789/554
dc.description.abstract Tuberculosis (TB) is an airborne disease caused by Mycobacterium tuberculosis. TB is the leading cause of morbidity and mortality in the developing world. Early and accurate diagnosis of TB would greatly enhance the treatment and prevention of the disease. Current methods of TB detection suffer from various limitations such as low specificity and sensitivity, being too complex and expensive. In the present work, we aim to develop an optical biosensor based on DNA aptamers, quantum dot (QD) crystals and magnetic nanoparticles (MNP) for detection of MPT64 protein, specific to M.tuberculosis. Aptamer-MNP conjugate is used for separation of MPT64 from solution, while aptamer-QD is used to detect its presence afterwards using fluorometer. ru_RU
dc.language.iso en ru_RU
dc.publisher Nazarbayev University ru_RU
dc.subject first research week ru_RU
dc.subject healthcare problems ru_RU
dc.subject Tuberculosis control ru_RU
dc.subject optical biosensor ru_RU
dc.title Development of an optical biosensor for diagnosis of tuberculosis ru_RU
dc.type Abstract ru_RU

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