Hyperglycemia induced epigenetic changes and cell migration
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Date
2014
Authors
Zhalmagambetov, B.
Orakov, A.
Gilman, C.
Journal Title
Journal ISSN
Volume Title
Publisher
Nazarbayev University
Abstract
Cancer is responsible for millions of deaths annually1. Especially, cancer in overweight people
becoming to pose a threat as some cancers are becoming resistant to chemotherapy 2 , 3 . In addition,
most overweight people have a diabetes or hyperglycemia. Although it was shown that hyperglycemia
can trigger epigenetic changes in many cancer cells, there is no data how hyperglycemia would affects
migration through epigenetic alterations. We aim to study abovementioned by assessing the cell migration
under hyperglycemic conditions on glioblastoma cells and the specific epigenetic changes associated with
hyperglycemia. We will use immunofluorescence, bisulfate conversion sequencing to assess epigenetic
status and do scratch assay to study cell migration. Our results can shed light on the effect of epigenetic
changes to cell migration under hyperglycemic conditions.
Description
Keywords
diabetes, hyperglycemia, glioblastoma cells, epigenetic changes, immunofluorescence, cell migration, chemotherapy, cell