DSpace Repository

CHANGE IN COLLAGEN FIBRIL DIAMETER DISTRIBUTION OF BOVINE ANTERIOR CRUCIATE LIGAMENT UPON INJURY CAN BE MIMICKED IN A NANOSTRUCTURED SCAFFOLD

Show simple item record

dc.contributor.author Beisbayeva, Zhuldyz
dc.contributor.author Zhanbassynova, Ainur
dc.contributor.author Kulzhanova, Gulzada
dc.contributor.author Mukasheva, Fariza
dc.contributor.author Erisken, Cevat
dc.date.accessioned 2021-04-23T08:13:16Z
dc.date.available 2021-04-23T08:13:16Z
dc.date.issued 2021-02-24
dc.identifier.citation Beisbayeva Z, Zhanbassynova A, Kulzhanova G, Mukasheva F, Erisken C. Change in Collagen Fibril Diameter Distribution of Bovine Anterior Cruciate Ligament upon Injury Can Be Mimicked in a Nanostructured Scaffold. Molecules. 2021; 26(5):1204. https://doi.org/10.3390/molecules26051204 en_US
dc.identifier.uri http://nur.nu.edu.kz/handle/123456789/5369
dc.description.abstract More than 200,000 people are suffering from Anterior Cruciate Ligament (ACL) related injuries each year in the US. There is an unmet clinical demand for improving biological attachment between grafts and the host tissue in addition to providing mechanical support. For biological graft integration, it is important to provide a physiologically feasible environment for the host cells to enable them to perform their duties. However, behavior of cells during ACL healing and the mechanism of ACL healing is not fully understood partly due to the absence of appropriate environment to test cell behavior both in vitro and in vivo. This study aims at (i) investigating the change in fibril diameter of bovine ACL tissue upon injury and (ii) fabricating nanofiber-based scaffolds to represent the morphology and structure of healthy and injured ACL tissues. We hypothesized that distribution and mean diameter of ACL fibrils will be altered upon injury. Findings revealed that the collagen fibril diameter distribution of bovine ACL changed from bimodal to unimodal upon injury with subsequent decrease in mean diameter...... en_US
dc.language.iso en en_US
dc.publisher Molecules en_US
dc.rights Attribution-NonCommercial-ShareAlike 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/us/ *
dc.subject injury en_US
dc.subject anterior cruciate ligament en_US
dc.subject bovine en_US
dc.subject collagen en_US
dc.subject diameter en_US
dc.title CHANGE IN COLLAGEN FIBRIL DIAMETER DISTRIBUTION OF BOVINE ANTERIOR CRUCIATE LIGAMENT UPON INJURY CAN BE MIMICKED IN A NANOSTRUCTURED SCAFFOLD en_US
dc.type Article en_US
workflow.import.source science


Files in this item

The following license files are associated with this item:

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-ShareAlike 3.0 United States Except where otherwise noted, this item's license is described as Attribution-NonCommercial-ShareAlike 3.0 United States

Video Guide

Submission guideSubmission guide

Submit your materials for publication to

NU Repository Drive

Browse

My Account

Statistics