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dc.contributor.author | Wassim Y., Almawi![]() |
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dc.contributor.author | Sana, Mahjoub![]() |
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dc.contributor.author | Vera, Chayeb![]() |
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dc.contributor.author | Hedia, Zitouni![]() |
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dc.contributor.author | Rabeb M., Ghali![]() |
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dc.contributor.author | Haifa, Regaieg![]() |
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dc.contributor.author | Touhami, Mahjoub![]() |
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dc.date.accessioned | 2020-05-29T08:58:59Z | |
dc.date.available | 2020-05-29T08:58:59Z | |
dc.date.issued | 2019-10-11 | |
dc.identifier.citation | Mahjoub, S., Chayeb, V., Zitouni, H. et al. IKZF1 genetic variants rs4132601 and rs11978267 and acute lymphoblastic leukemia risk in Tunisian children: a case-control study. BMC Med Genet 20, 159 (2019). https://doi.org/10.1186/s12881-019-0900-1 | en_US |
dc.identifier.uri | https://doi.org/10.1186/s12881-019-0900-1 | |
dc.identifier.uri | http://nur.nu.edu.kz/handle/123456789/4758 | |
dc.description.abstract | Background Associations between IKZF1 gene variants and Acute Lymphoblastic Leukemia (ALL) was recently reported. We examined whether the common IKZF1 polymorphisms rs4132601 T/G and rs111978267 A/G are associated with ALL among a Tunisian pediatric cohort. Methods This case-control study involved 170 patients with ALL and 150 control subjects. SNP genotyping was performed by TaqMan® SNP Genotyping Assay. Results The minor allele G of IKZF1 gene polymorphism rs4132601 T/G was significantly higher in ALL cases than in control subjects (P = 0.029), with 1.54-fold increased risk of ALL. The association of rs4132601 with ALL was seen under co-dominant (P = 0.009), recessive (P = 0.006), and additive (P = 0.027) genetic models, of which the co-dominant (P = 0.027) and recessive (P = 0.027) association remained significant after adjusting for covariates, and False Discovery Rate correction. In contrast, no association was noted for rs111978267 variant. Two-locus (rs4132601-rs11978267) IKZF1 haplotype analysis demonstrated association of GA (P = 0.053), with increased ALL risk [OR (95% CI) = 1.58 (1.00–2.51)], which remained significant after controlling for key covariates [aP = 0.046; aOR (95% CI) = 1.61 (1.01–2.57)]. Conclusion We demonstrated the association of IKZF1 polymorphism rs4132601 T/G with increased risk of ALL among Tunisian pediatric cohort, with altered phenotypic changes among ALL patients. | en_US |
dc.language.iso | en | en_US |
dc.publisher | BMC | en_US |
dc.rights | Attribution-NonCommercial-ShareAlike 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/us/ | * |
dc.title | IKZF1 genetic variants rs4132601 and rs11978267 and acute lymphoblastic leukemia risk in Tunisian children: a case-control study | en_US |
dc.type | Article | en_US |
workflow.import.source | science |
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