Genetic predisposition to celiac disease in Kazakhstan: Potential impact on the clinical practice in Central Asia
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Date
2020-01-02
Authors
Poddighe, Dimitri
Turganbekova, A.
Baymukasheva, Dana
Saduakas, Zhazira
Zhanzakova, Zhuldyz
Abdrakhmanova, S.
Journal Title
Journal ISSN
Volume Title
Publisher
PLoS One
Abstract
Background
Celiac disease (CD) is a systemic immune-mediated disorder developing in HLA genetically predisposed individuals carrying HLA-DQ2 and/or HLA-DQ8 molecules. Recent evidences supported a predominant importance of HLA-DQB1 locus and, in particular, HLA-DQB1*02 alleles. This diagnosis is poorly considered in Kazakhstan, because of the assumption that CD is not prevalent in this population.
Objective
To demonstrate that the genetic predisposition to CD in Kazakhstan is not negligible and is actually comparable to Western populations.
Methods
Through the analysis of HLA-DQ genotypes of healthy bone marrow donors from Kazakhstan’s national registry, we estimated the HLA-related genetic predisposition to CD in the country.
Results
We demonstrated that the frequency of CD-related HLA-DQB1 alleles and, as a consequence, of predisposed individuals to CD in Kazakhstan is significant and comparable to countries with the highest disease prevalence.
Conclusion
Considering the dietary style in Kazakhstan, including wheat as a staple food, these results provided a preliminary background of knowledge to expect a significant CD prevalence in Kazakhstan and Central Asia by implementing appropriate and cost-effective diagnostic strategies.
Description
Keywords
Research Subject Categories::NATURAL SCIENCES::Biology
Citation
Poddighe, D., Turganbekova, A., Baymukasheva, D., Saduakas, Z., Zhanzakova, Z., & Abdrakhmanova, S. (2020). Genetic predisposition to celiac disease in Kazakhstan: Potential impact on the clinical practice in Central Asia. PloS one, 15(1).