PIPK1b regulates E-cadherin endocytosis in polarized breast cancer cells and promotes a switch to a migratory phenotype
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Date
2014
Authors
Azhunussova, A.
Shayakhmetov, Y.
Chao, W. T.
Kunz, J.
Journal Title
Journal ISSN
Volume Title
Publisher
Nazarbayev University
Abstract
The endocytosis, degradation, and recycling of cadherins is crucial for the dynamic
regulation of adherens junctions and the control of cell-cell adhesion during tissue formation and in
many pathological conditions. In order to allow for dynamic changes in intercellular adhesion, adherens
junctions assemble and disassemble in a continuous fashion. A key mechanism for modulating adhesion
strength is the adjustment of the cell surface levels of E-cadherin, the major component of adherens
junctions. E-cadherin endocytosis, often accompanied by its degradation, has been observed in many
developmental and disease processes and accounts for more rapid changes in adhesion strength that can
occur independently of the transcriptional regulation of E-cadherin. However, the molecular mechanisms
underlying E-cadherin endocytosis and recycling remain incompletely understood.
Description
Keywords
endocytosis, degradation, cadherins, dynamic regulation, pathological conditions, migratory phenotype