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L Chromosome Behaviour and Chromosomal Imprinting in Sciara Coprophila

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dc.contributor.author Singh, Prim B.
dc.contributor.author Belyakin, Stepan
dc.date.accessioned 2019-04-25T10:30:19Z
dc.date.available 2019-04-25T10:30:19Z
dc.date.issued 2018-09-03
dc.identifier.uri http://dx.doi.org/10.3390/genes9090440
dc.identifier.uri http://nur.nu.edu.kz/handle/123456789/3859
dc.description.abstract The retention of supernumerary chromosomes in the germ-line of Sciara coprophila is part of a highly-intricate pattern of chromosome behaviours that have fascinated cytogeneticists for over 80 years. Germ-line limited (termed L or “limited”) chromosomes are cytologically heterochromatic and late-replicating, with more recent studies confirming they possess epigenetic hallmarks characteristic of constitutive heterochromatin. Little is known about their genetic constitution although they have been found to undergo cycles of condensation and de-condensation at different stages of development. Unlike most supernumeraries, the L chromosomes in S. coprophila are thought to be indispensable, although in two closely related species Sciara ocellaris and Sciara reynoldsi the L chromosomes, have been lost during evolution. Here, we review what we know about L chromosomes in Sciara coprophila. We end by discussing how study of the L chromosome condensation cycle has provided insight into the site and timing of both the erasure of parental “imprints” and also the placement of a putative “imprint” that might be carried by the sperm into the egg. en_US
dc.language.iso en en_US
dc.rights Attribution-NonCommercial-ShareAlike 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/us/ *
dc.subject supernumerary chromosomes en_US
dc.subject heterochromatin en_US
dc.subject parent-of-origin effects en_US
dc.subject paternal X chromosome en_US
dc.subject maternal X chromosome en_US
dc.subject controlling element en_US
dc.title L Chromosome Behaviour and Chromosomal Imprinting in Sciara Coprophila en_US
dc.type Article en_US
workflow.import.source science

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