Abstract:
Tuberculosis (TB) remains a major health
problem in Kazakhstan. Despite of that the
rates of TB disease and mortality decreased
from 58,5/100000 and 4,1/100000 in 2015 to
52,7/100000 and 3,4/100000 in 2016
respectively, the rate of multidrug-resistant
TB (MDR-TB) increased from 12,2/100000
in 2014 to 13,5/100000 in 2015 [1];
MDR strains associated with resistance to
the main two first line anti-TB drugs –
isoniazid and rifampicin are the most
dangerous. 27 countries relate to high
MDR-TB burden countries, 15 of them in
the European region, including
Kazakhstan [2];
Methods of genotyping of M. tuberculosis
play important role in TB infection control.
There are more than 10 methods of
genotyping, MIRU-VNTR is one of the widely
used method in the world.