dc.contributor.author |
Dichello, Gennaro A.
|
|
dc.contributor.author |
Fukuda, Takahiro
|
|
dc.contributor.author |
Maekawa, Toru
|
|
dc.contributor.author |
Whitby, Raymond L.D.
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|
dc.contributor.author |
Mikhalovsky, Sergey V.
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|
dc.contributor.author |
Alavijeh, Mohammed
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|
dc.contributor.author |
Pannala, Ananth S.
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|
dc.contributor.author |
Sarker, Dipak K.
|
|
dc.creator |
Gennaro A., Dichello |
|
dc.date.accessioned |
2017-12-22T09:07:52Z |
|
dc.date.available |
2017-12-22T09:07:52Z |
|
dc.date.issued |
2017-07-15 |
|
dc.identifier |
DOI:10.1016/j.ejps.2017.05.001 |
|
dc.identifier.citation |
Gennaro A. Dichello, Takahiro Fukuda, Toru Maekawa, Raymond L.D. Whitby, Sergey V. Mikhalovsky, Mohammed Alavijeh, Ananth S. Pannala, Dipak K. Sarker, Preparation of liposomes containing small gold nanoparticles using electrostatic interactions, In European Journal of Pharmaceutical Sciences, Volume 105, 2017, Pages 55-63 |
en_US |
dc.identifier.issn |
09280987 |
|
dc.identifier.uri |
https://www.sciencedirect.com/science/article/pii/S0928098717302294 |
|
dc.identifier.uri |
http://nur.nu.edu.kz/handle/123456789/3057 |
|
dc.description.abstract |
Abstract The development of liposome-nanoparticle colloid systems offers a versatile approach towards the manufacture of multifunctional therapeutic platforms. A strategy to encapsulate small metallic nanoparticles (<4nm) within multilamellar vesicles, effected by exploiting electrostatic interactions was investigated. Two liposome-gold nanoparticle (lipo-GNP) systems were prepared by the reverse-phase evaporation method employing cationic or anionic surface functionalised particles in combination with oppositely charged lipid compositions with subsequent post-formulation PEGylation. Structural characterisation using electron microscopy and elemental analysis revealed a regular distribution of GNPs between adjacent lipid bilayers of intact liposomes. Nanoparticle encapsulation efficacy of the two lipo-GNP systems was revealed to be significantly different (p=0.03), evaluated by comparing the ratio of measured lipid to gold concentration (loading content) determined by a colorimetric assay and atomic emission spectroscopy, respectively. It was concluded that the developed synthetic strategy is an effective approach for the preparation of liposome-nanoparticle colloids with potential to control the relative concentration of encapsulated particles to lipids by providing favourable electrostatic interactions. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
European Journal of Pharmaceutical Sciences |
en_US |
dc.relation.ispartof |
European Journal of Pharmaceutical Sciences |
|
dc.subject |
Nanoparticle |
en_US |
dc.subject |
Liposome |
en_US |
dc.subject |
Encapsulation |
en_US |
dc.subject |
Electrostatic interaction |
en_US |
dc.subject |
Loading content |
en_US |
dc.title |
Preparation of liposomes containing small gold nanoparticles using electrostatic interactions |
en_US |
dc.type |
Article |
en_US |
dc.rights.license |
© 2017 Elsevier B.V. All rights reserved. |
|
elsevier.identifier.doi |
10.1016/j.ejps.2017.05.001 |
|
elsevier.identifier.eid |
1-s2.0-S0928098717302294 |
|
elsevier.identifier.pii |
S0928-0987(17)30229-4 |
|
elsevier.identifier.scopusid |
85019127007 |
|
elsevier.volume |
105 |
|
elsevier.coverdate |
2017-07-15 |
|
elsevier.coverdisplaydate |
15 July 2017 |
|
elsevier.startingpage |
55 |
|
elsevier.endingpage |
63 |
|
elsevier.openaccess |
0 |
|
elsevier.openaccessarticle |
false |
|
elsevier.openarchivearticle |
false |
|
elsevier.teaser |
The development of liposome-nanoparticle colloid systems offers a versatile approach towards the manufacture of multifunctional therapeutic platforms. A strategy to encapsulate small metallic nanoparticles... |
|
elsevier.aggregationtype |
Journal |
|
workflow.import.source |
science |
|