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dc.contributor.author | Tsoy, Andrey![]() |
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dc.contributor.author | Shalakhmetova, Tamara![]() |
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dc.contributor.author | Umbayev, Bauyrzhan![]() |
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dc.contributor.author | Askarova, Sholpan![]() |
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dc.creator | Andrey, Tsoy | |
dc.date.accessioned | 2017-12-13T05:21:50Z | |
dc.date.available | 2017-12-13T05:21:50Z | |
dc.date.issued | 2014-07-01 | |
dc.identifier | DOI:10.1016/j.jalz.2014.07.014 | |
dc.identifier.citation | Andrey Tsoy, Tamara Shalakhmetova, Bauyrzhan Umbayev, Sholpan Askarova, ROLE OF ROS IN AB42-MEDIATED ACTIVATION OF CEREBRAL ENDOTHELIAL CELLS, In Alzheimer's & Dementia, Volume 10, Issue 4, Supplement, 2014, Page P875 | en_US |
dc.identifier.issn | 15525260 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S1552526014025126 | |
dc.identifier.uri | http://nur.nu.edu.kz/handle/123456789/2863 | |
dc.description.abstract | There is evidence that the deposition of amyloid-beta peptide (Aβ) in brain parenchyma and brain vessels is the main cause of neuronal dysfunction in Alzheimer's disease (AD). Aβ exhibits multiple cytotoxic effects to neurons and causes dysfunction of the blood brain barrier (BBB). In the AD brains an increased deposition of Aβ in the cerebral vasculature is correlated with increased transmigration of blood-born inflammatory cells and neurovascular inflammation. However, regulatory mediators of these processes remain to be elucidated. In this study, we examined a role of ROS in actin polymerization and expression of adhesion molecules on the surface of the cerebral endothelial cells (CECs) that are activated by Aβ42. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Alzheimer's & Dementia | en_US |
dc.relation.ispartof | Alzheimer's & Dementia | |
dc.rights | Open Access - the content is available to the general public | en_US |
dc.title | Role of ros in ab42-mediated activation of cerebral endothelial cells | en_US |
dc.type | Article | en_US |
dc.rights.license | Copyright © 2014 Published by Elsevier B.V. | |
elsevier.identifier.doi | 10.1016/j.jalz.2014.07.014 | |
elsevier.identifier.eid | 1-s2.0-S1552526014025126 | |
elsevier.identifier.pii | S1552-5260(14)02512-6 | |
elsevier.volume | 10 | |
elsevier.issue.identifier | 4 | |
elsevier.issue.name | Alzheimer's Association International Conference 2014 | |
elsevier.coverdate | 2014-07-01 | |
elsevier.coverdisplaydate | July 2014 | |
elsevier.startingpage | P875 | |
elsevier.openaccess | 0 | |
elsevier.openaccessarticle | false | |
elsevier.openarchivearticle | false | |
elsevier.aggregationtype | Journal | |
workflow.import.source | science |
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