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Macroporous Composite Cryogels with Embedded Polystyrene Divinylbenzene Microparticles for the Adsorption of Toxic Metabolites from Blood

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dc.contributor.author Eichhorn, Tanja
dc.contributor.author Ivanov, Alexander E.
dc.contributor.author Dainiak, Maria B.
dc.contributor.author Leistner, André
dc.contributor.author Linsberger, Ingrid
dc.contributor.author Jungvid, Hans
dc.contributor.author Mikhalovsky, Sergey V.
dc.contributor.author Weber, Viktoria
dc.date.accessioned 2017-11-09T06:32:41Z
dc.date.available 2017-11-09T06:32:41Z
dc.date.issued 2013
dc.identifier.citation Eichhorn Tanja et al.(>7), 2013, Macroporous Composite Cryogels with Embedded Polystyrene Divinylbenzene Microparticles for the Adsorption of Toxic Metabolites from Blood, Journal of Chemistry, vol.2013, 8 pages ru_RU
dc.identifier.uri http://dx.doi.org/10.1155/2013/348412
dc.identifier.uri http://nur.nu.edu.kz/handle/123456789/2771
dc.description.abstract Composite monolithic adsorbents were prepared by the incorporation of neutral polystyrene divinylbenzene (PS-DVB) microparticles into macroporous polymer structures produced by cryogelation of agarose or poly(vinyl alcohol). The composite materials exhibited excellent flow-through properties. Scanning electron microscopy of the composite cryogels revealed that the microparticles were covered by thin films of poly(vinyl alcohol) or agarose and thus were withheld in the monolith structure. Plain PS-DVB microparticles showed efficient adsorption of albumin-bound toxins related to liver failure (bilirubin and cholic acid) and of cytokines (tumor necrosis factor-alpha and interleukin-6). The rates of adsorption and the amount of adsorbed factors were lower for the embedded microparticles as compared to the parent PS-DVB microparticles, indicating the importance of the accessibility of the adsorbent pores. Still, the macroporous composite materials showed efficient adsorption of albuminbound toxins related to liver failure as well as efficient binding of cytokines, combined with good blood compatibility. Thus, the incorporation of microparticles into macroporous polymer structures may provide an option for the development of adsorption modules for extracorporeal blood purification. ru_RU
dc.language.iso en ru_RU
dc.publisher Journal of Chemistry ru_RU
dc.rights Open Access - the content is available to the general public ru_RU
dc.rights Attribution-NonCommercial-ShareAlike 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/us/ *
dc.subject monolithic adsorbents ru_RU
dc.subject PS-DVB ru_RU
dc.subject poly ru_RU
dc.subject blood ru_RU
dc.title Macroporous Composite Cryogels with Embedded Polystyrene Divinylbenzene Microparticles for the Adsorption of Toxic Metabolites from Blood ru_RU
dc.type Article ru_RU


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