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Novel Small Molecule Inhibitors of Cancer Stem Cell Signaling Pathways

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dc.contributor.author Abetov, Danysh
dc.contributor.author Mustapova, Zhanar
dc.contributor.author Saliev, Timur
dc.contributor.author Bulanin, Denis
dc.contributor.author Batyrbekov, Kanat
dc.contributor.author Gilman, Charles P.
dc.date.accessioned 2017-01-12T09:49:37Z
dc.date.available 2017-01-12T09:49:37Z
dc.date.issued 2015-12-01
dc.identifier.citation Abetov, D., Mustapova, Z., Saliev, T., Bulanin, D., Batyrbekov, K., & Gilman, C. P. (2015). Novel Small Molecule Inhibitors of Cancer Stem Cell Signaling Pathways. Stem Cell Reviews and Reports, 11(6), 909-918. DOI: 10.1007/s12015-015-9612-x ru_RU
dc.identifier.uri http://nur.nu.edu.kz/handle/123456789/2256
dc.description.abstract The main aim of oncologists worldwide is to understand and then intervene in the primary tumor initiation and propagation mechanisms. This is essential to allow targeted elimination of cancer cells without altering normal mitotic cells. Currently, there are two main rival theories describing the process of tumorigenesis. According to the Stochastic Model, potentially any cell, once defunct, is capable of initiating carcinogenesis. Alternatively the Cancer Stem Cell (CSC) Model posits that only a small fraction of undifferentiated tumor cells are capable of triggering carcinogenesis. Like healthy stem cells, CSCs are also characterized by a capacity for self-renewal and the ability to generate differentiated progeny, possibly mediating treatment resistance, thus leading to tumor recurrence and metastasis. Moreover, molecular signaling profiles are similar between CSCs and normal stem cells, including Wnt, Notch and Hedgehog pathways. Therefore, development of novel chemotherapeutic agents and proteins (e.g., enzymes and antibodies) specifically targeting CSCs are attractive pharmaceutical candidates. This article describes small molecule inhibitors of stem cell pathways Wnt, Notch and Hedgehog, and their recent chemotherapy clinical trials. ru_RU
dc.language.iso en ru_RU
dc.publisher Stem Cell Reviews and Reports ru_RU
dc.rights Attribution-NonCommercial-ShareAlike 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/us/ *
dc.subject cancer ru_RU
dc.subject hedgehog ru_RU
dc.subject inhibitor ru_RU
dc.subject notch ru_RU
dc.subject signaling pathway ru_RU
dc.subject stem cells ru_RU
dc.subject wnt ru_RU
dc.title Novel Small Molecule Inhibitors of Cancer Stem Cell Signaling Pathways ru_RU
dc.type Article ru_RU

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