Cancer cells response on the microtubuler-inhibiting drugs
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Date
2016-05
Authors
Balabiyev, A.
Kakpenova, A.
Kauanova, S.
Vorobjev, I.A.
Journal Title
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Abstract
Cancer is one of the age-related diseases with detrimental impact on people
survival. Improvement of cancer therapies is a major focus of many scientists around the world.
Anticancer drugs based on the microtubules inhibition are successfully used to treat widerange
of cancers. Anti-microtubules drugs directly bind to colchicine, vinca and taxol binding
sites on beta-tubulin, resulting in the impairment of spindle formation, vesicle transport, cell
structure and migration. One of the modes of action anti-tubulin drugs is through causing faults
in mitotic spindle function, which lead to the prolonged mitotic block and consequently to cell
death. Although, drugs' high toxicity and development of resistance in patients lead to the idea
of revisiting the dosage and combination therapies of anti-tubulin drugs, some sources reported
that cell migration is more sensitive to microtubule inhibiting drugs than to cell proliferation
in endothelial cells. Previously, we reported observations on NIH/3T3 (normal fibroblasts) cell
proliferative activity, cell migration and direct test of microtubule dynamics. Thus, we aimed to
identify effect of microtubule inhibitors on cancer cell lines. In addition, we compare normal cell
lines with human cancer cell lines such as A549 (lung carcinoma), HT1080 (fibrosarcoma) and
U118 (glioma).
Description
Keywords
Cancer, cancer therapies, Anticancer drugs, microtubules inhibiting drugs
Citation
Balabiyev A., Kakpenova A., Kauanova S., and Vorobjev I.A. 2016. Cancer cells response on the microtubuler-inhibiting drugs. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1512