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Placental Failure in Mice Lacking the Mammalian Homolog of Glial Cells Missing, GCMa

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dc.contributor.author Riethmacher-Sonnenberg, Eva
dc.date.accessioned 2016-03-30T03:36:52Z
dc.date.available 2016-03-30T03:36:52Z
dc.date.issued 2000
dc.identifier.citation Riethmacher-Sonnenberg Eva; 2000; Placental Failure in Mice Lacking the Mammalian Homolog of Glial Cells Missing, GCMa; MOLECULAR AND CELLULAR BIOLOGY ru_RU
dc.identifier.uri http://nur.nu.edu.kz/handle/123456789/1351
dc.description.abstract The GCM family of transcription factors consists of Drosophila melanogaster GCM, an important regulator of gliogenesis in the fly, and its two mammalian homologs, GCMa and GCMb. To clarify the function of these mammalian homologs, we deleted GCMa in mice. Genetic ablation of murine GCMa (mGCMa) is embryonic lethal, with mice dying between 9.5 and 10 days postcoitum. At the time of death, no abnormalities were apparent in the embryo proper. Nervous system development, in particular, was not impaired, as might have been expected in analogy to Drosophila GCM. Instead, placental failure was the cause of death. In agreement with the selective expression of mGCMa in labyrinthine trophoblasts, mutant placentas did not develop a functional labyrinth layer, which is necessary for nutrient and gas exchange between maternal and fetal blood. Only a few fetal blood vessels entered the placenta, and these failed to thrive and branch normally. Labyrinthine trophoblasts did not differentiate. All other layers of the placenta, including spongiotrophoblast and giant cell layer, formed normally. Our results indicate that mGCMa plays a critical role in trophoblast differentiation and the signal transduction processes required for normal vascularization of the placenta ru_RU
dc.language.iso en ru_RU
dc.publisher American Society for Microbiology ru_RU
dc.rights Attribution-NonCommercial-ShareAlike 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/us/ *
dc.subject Research Subject Categories::NATURAL SCIENCES::Biology::Organism biology::Microbiology ru_RU
dc.subject Drosophila melanogaster GCM ru_RU
dc.subject Glial Cells Missing ru_RU
dc.subject Mammalian Homolog ru_RU
dc.title Placental Failure in Mice Lacking the Mammalian Homolog of Glial Cells Missing, GCMa ru_RU
dc.type Article ru_RU


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