Browsing 13.Materials of Forums, Conferences and Projects by Subject "biochemical"

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Genetic dissection of the biochemical activities of human DNA repair protein, APE1

Redrejo-Rodriguez, M.; Mursalimov, A.; Koshenov, Z.; Zhakupova, K.; Saparbaev, M. K.; Ishchenko, A. A.; Matkarimov, B. (Nazarbayev University, 2014)

Human apurinic/apyrimidinic endonuclease 1 (APE1) is a key DNA repair enzyme involved in both base excision repair (BER) and nucleotide incision repair (NIR) pathways. In the BER pathway, APE1 cleaves DNA at AP sites and ...
PIPK1a regulates RAC1 and akt activation to promote cell migration and proliferation

Merzhakupova, D.; Adilgozhina, G.; Kim, A.; Chao, W. T.; Kunz, J. (Nazarbayev University, 2014)

Rac1 activity is concentrated at the front of migrating cells where it initiates signaling processes necessary for cell migration in normal and pathological situations. The signaling pathways downstream of Rac1 are well ...
SNX 9 interacts with dynamin 2 and N-wasp to regulate focal adhesion disassembly and cell migration

Zhubanchaliyev, A.; Chao, W. T.; Kunz, J. (Nazarbayev University, 2014)

The turnover of focal adhesions is essential for normal cell migration and tumor invasion, but the underlying mechanisms are poorly understood. We have previously shown that the disassembly of focal adhesions occurs by ...