Antigen Specificity Enhances Disease Control by Tregs in Vitiligo

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2023-01-01

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AAAS

Abstract

Tregs engineered to express a TCR specific to melanocyte antigens provide superior disease control in a mouse model of vitiligo, homing to skin, persisting long-term, and suppressing effector T cells more effectively than polyclonal Tregs.

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type of access: open access, autoimmunity, antigen specificity, immune tolerance, vitiligo, Tregs, Tregs

Citation

Engelhard, V. H. H.; Overacre-Delgoffe, A. C.; Haughney, J. F.; et al. (2023). Antigen Specificity Enhances Disease Control by Tregs in Vitiligo. Science Translational Medicine, 15(691), eabn2748. https://doi.org/10.1126/scitranslmed.abn2748

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https://doi.org/10.1126/scitranslmed.abn2748
 https://nur.nu.edu.kz/handle/123456789/9582

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