Browsing by Subject "metabolism"

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Polymorphisms in genes involved in the absorption, distribution, metabolism, and excretion of drugs in the Kazakhs of Kazakhstan

Iskakova, Aisha N.; Romanova, Aliya A.; Aitkulova, Akbota M.; Sikhayeva, Nurgul S.; Zholdybayeva, Elena V.; Ramanculov, Erlan M. (BMC Genetics, 2016-01-19)

Background: Studies of genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs are crucial to the development of therapeutics in clinical medicine. Such data provide information that may ...
Study the effect of gene polymorphism contribution of statin biotransformation and lipid metabolism for parameters of statin efficacy. Recruiting

Kozhakhmetov, S.S.; Kushugulova, A.R.; Kakimova, A.B.; Saduakhassova, S.A.; Urasova, M.S.; Khassenbekova, Zh.R.; Kozhakhmetova, S.S.; Kazhybayev, A.K.; Urazbayeva, G.S.; Tuleutayeva, G.K.; Ongarbayeva, A.E.; Beysembayeva, S.Ch.; Nurgozhin, T.S.; Zhumadilov, Zh. (National Laboratory Astana, Nazarbayev University 2016, 2016-05-11)

Rosuvastatin is high-performance hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase, which commonly used in the treatment of hyperlipidemia. It significantly reduces levels of LDL, which accompanied by a moderate increase ...