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Browsing by Author "Askarova, Sh."

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Activation of cell ageing pathways with novel small molecules for cancer treatment

Masoud, A.; Brook, A.; Davis, T.; Umbayev, B.; Tsoy, A.; Askarova, Sh.; Kipling, D.; Alimbetov, D. (National Laboratory Astana, Nazarbayev University, 2017-09-15)
Antioxidant and anti-inflammatory properties of plant extract from Limonium Gmelinii

Tsoy, А.; Abzhanova, E.; Turgambayeva, A.; Zhussupova, G.; Shalakhmetova, T.; Nurkenov, T.; Askarova, Sh. (National Laboratory Astana, Nazarbayev University, 2017-09-15)
Assesing the cytokine content of human platelet-rich plasma

Masoud, A.; Umbayev, B.; Olzhayev, F.; Idrissova, D.; Shramko, A.; Kaiyrlykyzy, A.; Askarova, Sh. (2016-05)

Human platelet-rich plasma (PRP) is plasma that is enriched with thrombocytes at a concentration of 1000 * 109 per litre, higher than normal (150 - 350 * 109 per litre). Thrombocytes are known to contain growth factors ...
Astroprotective potential of extract from limonium gmelinii for stroke therapy

Shayakhmetov, Y.; Tsoy, A.; Zhussupova, G.; Askarova, Sh. (2016-05)

It's known that proinflammatory cytokines, such asTNF-a, produced by injured neurons and infiltrated leukocytes, involved in every aspect of stroke. Cytokines promote activation of astroglia, induce oxidative stress ...
Biocompatibility of new thermoreversible poloxamer 407-based hydrogels

Masoud, A.; Olzhayev, F.; Askarova, Sh.; Shramko, A.; Sadyrbekov, D.; Safarova, Y.; Tsoy, A.; Umbayev, B. (National Laboratory Astana, Nazarbayev University, 2017-09-15)
Mesenchymal stem cells and osteophilic polymer as promising agents in bone regeneration

Yantsen, Y.; Idrissova, D.; Olzhayev, F.; Umbayev, B.; Murata, H.; Russell, A.; Askarova, Sh. (Center for Life Sciences, Nazarbayev University, 2014)

Mesenchymal stem cells (MSCs) are an attractive stem cell source for transplantation. MSCs can easily differentiate into osteoblasts and increase in osteoblast number will have positive effect on the bone regeneration in ...
MSCS functionalized with osteophilis polymer enhance compact bone regeneration in osteoporotics rat model in vivo

Safarova (Yantsen), Y.; OIzhayev, F.; ldrissova, D.; Umbayev, B.; Murata, H.; Koepsel, R.; Russell, A.; Askarova, Sh. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Undeniable increase in osteoporotic fractures is associated mainly with the global population aging. Age-related alterations shift bone metabolism to induced osteoclastic activity and reduction of osteoblasts that ...
Osteophilic polymer and mesenchymal stem cells in bone regeneration

Safarova (Yantsen), Y.; Olzhayev, F.; Umbayev, B.; Murata, H.; Russell, A.; Askarova, Sh. (National Laboratory Astana, Nazarbayev University, 2017-09-15)
Protocol optimization for abtaining lyophilized human amniotic membrane extract

Shramko, A.; Umbayev, В.; Olzhayev, R.; Idrissova, D.; Masoud, A.; Sadyrbekov, D.; Askarova, Sh. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

The amniotic membrane (AM) is the inner amniotic fluid-filled membrane which forms a cavity around the embryo. AM has long been used in the treatment of venous ulcers and burns. Freshly extracted AM has been shown to ...
Role of astrocyte aging in the pathogenesis of alzheimer`s disease

Imangali, N.; Alimbetov, D.; Tsoy, A.; Saparbayev, S.; Askarova, Sh. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Alzheimer's disease (AD) is the most abundant severe and irreversible neurodegenerative disease in the world that affects people over 65 years old. The major hallmarks of AD pathology are the senile p-amyloid plaques, ...
Β-amyloid results in elevated ros and cytokines levels in senescent human astrocytes

Alimbetov, D.; Tsoy, A.; Imangali, N.; Abzhanova, E.; Turgambayeva, A.; Saparbayev, S.; Askarova, Sh. (National Laboratory Astana, Nazarbayev University, 2017-09-15)