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Browsing by Author "Askapuli, A."

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Association of vitamin D receptor (FOKI, TAQI, APAI & BSMI) and IF-y genes' polymorphisms with risk of developing pulmonary TB (PTB) among Kazakhstani population

Yerezhepov, D.; Zhabagin, M.; Abilova, Zh.; Askapuli, A.; Abilmazhinova, A.; Rakhimova, S.; Kairov, U.; Molkenov, A.; Akhmetova, A.; Akilzhanova, A. (Nazarbayev University, 2014)

Almost one third of the world's population is infected with Mycobacterium tuberculosis (MTB) and only 10% of them will develop any active form of the disease. TB is second (1s t is HIV/AIDS) greatest killer worldwide due ...
Creating prerequisites of personalized approach in the diagnosis and treatment of tuberculosis, based on whole genome-sequencing of M.tuberculosis

Molkenov, A.; Abilmazhinova, A.; Akhmetova, A.; Chingisova, L.; Bismilda, V.; Yerezhepov, D.; Kozhamkulov, U.; Abilova, Zh.; Askapuli, A.; Zhabagin, M.; Kairov, U.; Rahimova, S.; Zhumadilov, Zh.; Akilzhanova, A. (Nazarbayev University, 2013)

The next generation sequencing technology provides a tool to obtain genetic data from clinically isolates M.tuberculosis. Using it we can clarify the factors cause of the formation of highly virulent strains of M.tuberculosis, ...
Genetic architecture of Kazakh population

Kairov, U.; Molkenov, A.; Zhabagin, M.; Askapuli, A.; Abilmazhinova, A.; Akhmetova, A.; Yerezhepov, D.; Abilova, Zh.; Rahimova, S.; Zhumadilov, Zh.; Akilzhanova, A. (Nazarbayev University, 2013)

The aim of the project is to define genetic architecture of Kazakh population by sequencing and analyzing whole exomes and whole genomes of Kazakhs living in different regions of Kazakhstan
Mapping of eco-social and genetic factors of susceptibility of tuberculosis among the population of the Rebuplic of Kazakhstan

Akhmetova, A.; Rakhimova, S.; Kairov, U.; Abilova, Zh.; Askapuli, A.; Zhabagin, M.; Yerezhepov, D.; Abilmazhinova, A.; Molkenov, A.; Akilzhanova, A. (Nazarbayev University, 2013)

In this study combined design was used, which included: 1) Case-control study; 2) Molecular epidemiological study; and 3) Study of human genetic susceptibility to tuberculosis.This work is the first case-control study in ...
Whole genome sequencing of mycobacterium tuberculosis in Kazakhstan: first sequence results of two clinical isolates

Molkenov, A.; Kairov, U.; Kozhamkulov, U.; Rakhimova, S.; Askapuli, A.; Zhabagin, M.; Abilova, Zh.; Akhmetova, A.; Yerezhepov, D.; Abilmazhinova, A.; Bismilda, V.; Chingisova, L.; Zhumadilov, Zh.; Akilzhanova, A. (Nazarbayev University, 2014)

The project is aimed to create the prerequisites for a personalized approach to the diagnosis and treatment of tuberculosis (TB) by identifying and comparing the whole genome sequences of M.tuberculosis strains isolated ...