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Browsing by Subject "Alzheimer’s disease"

Browsing by Subject "Alzheimer’s disease"

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  • Amyloid-b peptide on sialyl-LewisX-selectin-mediated membrane tether mechanics at the cerebral endothelial cell surface 
    Askarova, Sholpan; Sun, Zhe; Sun, Grace Y.; Meininger, Gerald A.; Lee, James C-M. (PLOS ONE:Open Access journal, 2013-04-12)
    Increased deposition of amyloid-b peptide (Ab) at the cerebral endothelial cell (CEC) surface has been implicated in enhancement of transmigration of monocytes across the brain blood barrier (BBB) in Alzheimer’s disease ...
  • CRITICAL ROLE OF BRAIN-SPECIFIC GANGLIOSIDES IN THE PATHOGENESIS OF TRAUMATIC BRAIN INJURY AND ALZHEIMER’S DISEASE 
    Ponomarev, Eugene D. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Major brain glycosphingolipids, also called brain gangliosides, are localized within neuronal lipid rafts (NLR) of neuronal axons and synapses and their role in neurodegenerative diseases remains unknown. Here, we compared ...
  • Dysfunction of Cerebral Endothelium in Alzheimer's disease 
    Askarova, Sholpan (2015)
    Alzheimer’s disease is the most common form of dementia in the elderly, which accounts up to 80 % of all cases. •Clinical manifestation of the disease includes cognitive impairments such as attention deficit, spatial ...
  • Effects of amyloid beta peptide on neurovascular cells 
    Askarova, Sholpan; Tsoy, Andrey; Shalakhmetova, Tamara; Lee, James C-M. (Central Asian Journal of Global Health, 2012)
    Alzheimer’s disease (AD) is a chronic neurodegenerative disorder, which is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in specific regions of the brain, accompanied by impairment of the ...
  • GUT MICROBIOME ALTERATIONS IN SENIORS SUFFERING FROM ALZHEIMER’S DISEASE 
    Askarova, Sholpan; Kaiyrlykyzy, Aiym; Kozhakhmetov, Samat S.; Nurgaziyev, Madiyar; Kushugulova, Almagul R. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Introduction: One of the important factors influencing human health and attracting increasing attention of scientists during the last two decades is gut microbiome. It has been demonstrated that the links exist between ...
  • MRI-BASED STUDY OF VARIOUS COGNITIVE IMPAIRMENTS: CROSS-SECTIONAL STUDY 
    Kossumov, Alibek; Supiyev, Adil (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)
    Introduction: Clinical and diagnostic criteria for cognitive impairments are based neurophysiological tests or the presence of a history of vascular disease and stroke following the MRI scan. Materials and methods: The ...
  • Rage targeted strategies for Alzheimer`s Amyloid B peptide include blood brain barrier dysfunctions 
    Askarova, Sholpan; Tsoy, A.; Lee, J.C-M. (Nazarbayev University, 2013)
    This study demonstrated that Aβ binding to RAGE at the CECs and astrocytes surface is required for NADPH oxidase complex assembling, resulting in subsequent ROS generation and phosphorylation of cPLA2α. Therefore, understanding ...