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AGE REPROGRAMMING AND EPIGENETIC REJUVENATION

Kulaissova, A.; Singh, Prim B. (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

Introduction: Age reprogramming represents a novel method for generating patient-specific tissues for transplantation. It bypasses the de-differentiation/re-differentiation cycle that is characteristic of the induced ...
BIOLOGY AND PHYSICS OF HETEROCHROMATIN-LIKE DOMAINS/COMPLEXESA DETAILED ASSESSMENT OF GROUNDWATER QUALITY IN THE KABUL BASIN, AFGHANISTAN, AND SUITABILITY FOR FUTURE DEVELOPMENT

Singh, Prim B.; Belyakin, Stepan N.; Laktionov, Petr P. (MDPI, 2020-08-11)

The hallmarks of constitutive heterochromatin, HP1 and H3K9me2/3, assemble heterochromatin-like domains/complexes outside canonical constitutively heterochromatic territories where they regulate chromatin template-dependent ...
Deletion of HP1γ in cardiac myocytes afects H4K20me3 levels but does not impact cardiac growth

El‑Nachef, Danny; Fang, Chen; Kajimoto, Hidemi; Brown, Jeremy P.; Singh, Prim B.; MacLellan, W. Robb (Epigenetics Chromatin, 2018-04-18)

Heterochromatin, which is formed when tri-methyl lysine 9 of histone H3 (H3K9me3) is bound by heterochromatin 1 proteins (HP1s), plays an important role in differentiation and senescence by silencing cell cycle genes. ...
L Chromosome Behaviour and Chromosomal Imprinting in Sciara Coprophila

Singh, Prim B.; Belyakin, Stepan (2018-09-03)

The retention of supernumerary chromosomes in the germ-line of Sciara coprophila is part of a highly-intricate pattern of chromosome behaviours that have fascinated cytogeneticists for over 80 years. Germ-line limited ...
Mammalian HP1 Isoforms Have Specific Roles in Heterochromatin Structure and Organization

Bosch-Presegue, Laia; Raurell-Vila, Helena; Thackray, Joshua K.; Singh, Prim B.; Serrano, Lourdes; Vaquero, Alejandro (Cell Reports, 2017)

HP1 is a structural component of heterochromatin. Mammalian HP1 isoforms HP1a, HP1b, and HP1g play different roles in genome stability, but their precise role in heterochromatin structure is unclear. Analysis of Hp1a ...
Maternal regulation of chromosomal imprinting in animals

Singh, Prim B.; Shloma, Victor V.; Belyakin, Stepan N. (SPRINGER, 2019-06)

Chromosomal imprinting requires an epigenetic system that imprints one of the two parental chromosomes such that it results in a heritable (cell-to-cell) change in behavior of the imprinted chromosome. Imprinting takes ...
On the relations of phase separation and Hi-C maps to epigenetics

Singh, Prim B.; Newman, Andrew G. (The Royal Society, 2020-03-04)

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. The ...