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BIOMATERIALS LOADED WITH GROWTH FACTORS/CYTOKINES AND STEM CELLS FOR CARDIAC TISSUE REGENERATION

Smagul, Saltanat; Kim, Yevgeniy; Smagulova, Aiganym; Raziyeva, Kamila; Nurkesh, Ayan; Saparov, Arman (MDPI, 2020-08)

Myocardial infarction causes cardiac tissue damage and the release of damage-associated molecular patterns leads to activation of the immune system, production of inflammatory mediators, and migration of various cells to ...
GENERATION OF PARTICLE ASSEMBLIES MIMICKING ENZYMATIC ACTIVITY BY PROCESSING OF HERBAL FOOD: THE CASE OF RHIZOMA POLYGONATI AND OTHER NATURAL INGREDIENTS IN TRADITIONAL CHINESE MEDICINE

Benassi, Enrico; Fan, Haiyan; Sun, Qinglei; Dukenbayev, Kanat; Wang, Qian; Shaimoldina, Ainur; Tassanbiyeva, Aigerim; Nurtay, Lazzat; Nurkesh, Ayan; Kutzhanova, Aidana; Mu, Chenglin; Dautov, Adilet; RAZBEKOVA, MADINA; Kabylda, Anar; Yang, Qing; Li, Ziye; Amin, Amr; Li, Xugang; Xie, Yingqiu (Royal Society of Chemistry, 2021-01-13)

Processed herbs have been widely used in eastern and western medicine; however, the mechanism of their medicinal effects has not yet been revealed. It is commonly believed that a central role is played by chemically active ...
MACROPHAGE POLARIZATION IN CARDIAC TISSUE REPAIR FOLLOWING MYOCARDIAL INFARCTION

Kim, Yevgeniy; Nurakhayev, Sanzhar; Nurkesh, Ayan; Zharkinbekov, Zharylkasyn; Saparov, Arman (International Journal of Molecular Sciences, 2021-03-08)

Cardiovascular disease is the leading cause of mortality and morbidity around the globe, creating a substantial socio-economic burden as a result. Myocardial infarction is a significant contributor to the detrimental ...
Nuclear MET requires ARF and is inhibited by carbon nanodots through binding to phospho-tyrosine in prostate cancer

Xie, Yingqiu; Fan, Haiyan; Wenfu, Lu; Yang, Qing; Nurkesh, Ayan; Yeleussizov, Tleubek; Maipas, Aisulu; Lu, Jiang; Manarbek, L.; Chen, Zh.; Benassi, E. (Nazarbayev University School of Sciences and Humanities, 2019-04-18)

Nuclear receptor tyrosine kinases (nRTKs) are aberrantly upregulated in many types of cancers, but the regulation of nRTK remains unclear. We previously showed androgen deprivation therapy (ADT) induces nMET in ...
PRECONDITIONED AND GENETICALLY MODIFIED STEM CELLS FOR MYOCARDIAL INFARCTION TREATMENT

Raziyeva, Kamila; Smagulova, Aiganym; Kim, Yevgeniy; Smagul, Saltanat; Nurkesh, Ayan; Saparov, Arman (MDPI, 2020-10)

Ischemic heart disease and myocardial infarction remain leading causes of mortality worldwide. Existing myocardial infarction treatments are incapable of fully repairing and regenerating the infarcted myocardium. Stem cell ...
RECENT ADVANCES IN THE CONTROLLED RELEASE OF GROWTH FACTORS AND CYTOKINES FOR IMPROVING CUTANEOUS WOUND HEALING

Nurkesh, Ayan; Jaguparov, Alexandr; Jimi, Shiro; Saparov, Arman (Frontiers Media, 2020-07)

Bioengineered materials are widely utilized due to their biocompatibility and degradability, as well as their moisturizing and antibacterial properties. One field of their application in medicine is to treat wounds by ...
SEQUENTIAL DELIVERY OF CRYOGEL RELEASED GROWTH FACTORS AND CYTOKINES ACCELERATES WOUND HEALING AND IMPROVES TISSUE REGENERATION

Jimi, Shiro; Jaguparov, Alexandr; Nurkesh, Ayan; Sultankulov, Bolat; Saparov, Arman (Frontiers in Bioengineering and Biotechnology, 2020-04)

Growth factors and cytokines that are secreted by cells play a crucial role in the complex physiological reaction to tissue injury. The ability to spatially and temporally control their actions to maximize regenerative ...
Systematic analysis of NLMP suggests nuclear localization of RTK/MET kinases resemble cancer cell clearance

Xie, Yingqiu; Nurkesh, Ayan; Ibragimova, Nazgul; Zhanzak, Zhuldyz; Meyerbekova, Aizhan; Alexeyeva, Zhanna; Yesbolatova, Aiya; Satayeva, Madina; Mustafa, Aidana; Manarbek, L.; Maipas, Aisulu; Altaikyzy, Akerke; Keneskhanova, Zhibek; Akbay, Burkitkan; Chen, Zhenbang (Nazarbayev University School of Sciences and Humanities, 2019-01-30)

BackgroundSome membrane proteins can translocate into the nucleus, defined as nuclear localized membrane proteins (NLMPs), including receptor tyrosine kinases (RTKs). We previously showed that nuclear MET (nMET), a member ...