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Protein kinase C inhibitors override ZEB1-induced chemoresistance in HC

Eugene, Tulchinsky; Sreekumar, Rahul; Emaduddin, Muhammad; Al-Saihati, Hajir; Moutasim, Karwan; Chan, James; Spampinato, Marcello; Bhome, Rahul; Yuen, Ho Ming; Mescoli, Claudia; Vitale, Alessandro; Cillo, Umberto; Rugge, Massimo; Primrose, John; Hilal, Mohammad Abu; Thirdborough, Stephen; Thomas, Gareth; Mirnezami, Alex; Sayan, A. Emre (Nature, 2019-09-23)

Epithelial–mesenchymal transition (EMT) is a process by which tumour cells lose epithelial characteristics, become mesenchymal and highly motile. EMT pathways also induce stem cell features and resistance to apoptosis. ...