02. Master's Thesis

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Browsing 02. Master's Thesis by Subject "antiproliferative"

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    INVESTIGATING AUTOPHAGY AS A POTENTIAL PATHWAY OF ANTICANCER MECHANISM OF PHENFORMIN
    (Nazarbayev University School of Medicine, 2024) Khikhmetova, Kamila
    Phenformin, a representative of the biguanides class, is an anti-diabetic drug that was withdrawn from the market due to its side effects profile is currently being investigated as a potential anticancer agent. Autophagy is an evolutionary conserved mechanism of lysosome-mediated catabolic breakdown of proteins, cellular compartments, and infectious agents for maintaining homeostasis. Activation of autophagy in cancer cell could potentially be one of the mechanisms of phenformin’s anticancer activity. This research aimed to establish the antiproliferative activity of phenformin among different cancer cell lines and to study the effect of phenformin on expression of proteins involved in autophagy in cervical cancer cells. Cervical cancer is the fourth leading cause of cancer mortality as well as the fourth most diagnosed cancer type in females. Our findings demonstrate that phenformin decreases the proliferation of various cancer cell lines in a dose-dependent manner cells and may have an ability to increase autophagic flux in cervical cancer cells.