Browsing by Author "Maratov, Madi"

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    PERIOSTIN IN INFLAMMATORY BOWEL DISEASE (IBD)
    (Nazarbayev University School of Medicine, 2023) Maratov, Madi
    The review summarizes current research findings on the link between inflammatory bowel disease (IBD) and periostin. IBD includes Crohn's disease (CD) and ulcerative colitis (UC). IBD can be caused by four established factors, namely genetic changes, environmental factors, microbiome changes, and immune dysfunction. It has been shown that during IBD, the concentration of serum periostin increases. This is because periostin level rises during tissue damage and allergic reactions. In fact, periostin exhibits six functions: cell recruitment, fibrosis, cell proliferation and apoptosis, activation of various cytokines, angiogenesis, and cancer development. Current studies show that periostin contributes to IBD's fibrogenesis, cell migration, and cell proliferation. Additionally, studies show that during IBD predominant location of periostin is around intestinal crypts, the expression of periostin increases in cell response to IL-6, IL-13, and TGF-β and periostin is associated with NF-kB and YAP/TAZ signaling pathways. Furthermore, the review discusses how periostin is involved in colitis-associated cancer and periostin’s predictive and therapeutic roles in IBD.