02. Master's Thesis

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Browsing 02. Master's Thesis by Author "Amangelsin, Yernar"

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    INVESTIGATING APOPTOSIS AS A POTENTIAL PATHWAY FOR ANTICANCER MECHANISM OF PHENFORMIN
    (Nazarbayev University School of Medicine, 2024) Amangelsin, Yernar
    Apoptosis is an essential cellular process that maintains cellular homeostasis. Dysregulation of apoptosis can lead to uncontrolled cell proliferation, which may result in the development of cancer. Targeting apoptosis has emerged as a promising strategy for cancer treatment. Biguanides, including metformin and phenformin, are known to activate AMP-activated protein kinase (AMPK) and have been identified as potential drugs for cancer prevention. It has been highlighted that phenformin has a greater antitumor activity compared to metformin. Because phenformin is more lipophilic and hence can easily enter the cells. Studies have proposed that phenformin's antiproliferative activity is attributed to its ability to induce cellular apoptosis. However, the anticancer activity and mechanism of apoptosis induction of phenformin can vary depending on the type of cancer. In light of this, we sought to evaluate the antiproliferative activity of phenformin on various cancer cell lines and to explore the role of apoptosis in phenformin's anticancer activity...