003.04. University Medial Center

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Browsing 003.04. University Medial Center by Author "Abbasi, Sepehr"

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    Influence of a modified preservation solution in kidney transplantation: A comparative experimental study in a porcine model
    (Asian Journal of Surgery, 2015) Golriz, Mohammad; Fonouni, Hamidreza; Kuttymuratov, Gani; Esmaeilzadeh, Majid; Jarahian, Parvin; Longerich, Thomas; Tahmasbi, Morva; Faridar, Alireza; Abbasi, Sepehr; Mehrabi, Arianeb; Gebhard, Marta M.
    Currently, due to lack of optimal donors, more marginal organs are transplanted. Therefore, there is a high interest to ameliorate preischemic organ preservation, especially for critical donor organs. In this regard, a new histidinetryptophane ketoglutarate (HTK-N) solution has been designed and its protective efficacy was compared with the standard preservation solutionsdUniversity of Wisconsin solution and standard HTK or Custodiol (Bretschneider’s solution). Methods: Seventy-two landrace pigs were included into the study, as donors and recipients. The donor kidneys were perfused during explantation with cold University of Wisconsin solution (n Z 12), standard HTK (n Z 12), or HTK-N solutions (n Z 12), kept in the respective preservation solution at 4 C for 30 hours, implanted in the recipient pigs, and reperfused. The pigs survived in daily control for 7 days. The serum creatinine and blood urea nitrogen were assessed in pre- and postreperfusion phase on the 3rd day and 7th day posttransplantation. Additionally, tissue samples were taken to analyze the histopathological degree of tubular injury and regeneration before and after reperfusion.