Lack of Clinical Manifestations in Asymptomatic Dengue Infection Is Attributed to Broad Down-Regulation and Selective Up-Regulation of Host Defence Response Genes
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Date
2014-04
Authors
Yeo, Adeline
Azhar, Nur Atiqah
Yeow, Wanyi
Talbot Jr., C. Conover
Asif Khan, Mohammad
Shankar, Esaki M.
Rathakrishnan, Anusyah
Azizan, Azliyati
Wang, Seok Mui
Kim Lee, Siew
Journal Title
Journal ISSN
Volume Title
Publisher
PLOS ONE:Open Access journal
Abstract
Dengue represents one of the most serious life-threatening vector-borne infectious diseases that afflicts approximately 50 million people across the globe annually. Whilst symptomatic infections are frequently reported, asymptomatic dengue remains largely unnoticed. Therefore, we sought to investigate the immune correlates conferring protection to individuals that remain clinically asymptomatic.
Description
Keywords
clinical manifestations, asymptomatic dengue, gene expression
Citation
Yeo ASL, Azhar NA, Yeow W, Talbot CC Jr, Khan MA, Shankar EM, et al. (2014) Lack of Clinical Manifestations in Asymptomatic Dengue Infection Is Attributed to Broad Down-Regulation and Selective Up-Regulation of Host Defence Response Genes. PLoS ONE 9(4): e92240. doi:10.1371/journal.pone.0092240