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Browsing School of Sciences and Humanities by Author "db187db1-b982-4eda-b8c8-54ea7f5c51e4"

Browsing School of Sciences and Humanities by Author "db187db1-b982-4eda-b8c8-54ea7f5c51e4"

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  • ACTIVITY-BASED PROBES TO UTILIZE THE PROTEOLYTIC ACTIVITY OF CATHEPSIN G IN BIOLOGICAL SAMPLES 
    Burster, Timo; Gärtner, Fabian; Knippschild, Uwe; Zhanapiya, Anuar (Frontiers in Chemistry, 2021-02-25)
    Neutrophils, migrating to the site of infection, are able to release serine proteases after being activated. These serine proteases comprise cathepsin G (CatG), neutrophil elastase protease 3 (PR3), and neutrophil serine ...
  • Antiviral Resistance of Splenocytes in Aged Mice 
    Burster, Timo (Nazarbayev University School of Sciences and Humanities, 2017-03-30)
    We compared the susceptibility to viral infection of splenocytes, isolated from young versus old CBA mice, and evaluated the antiviral actions of lactoferrin in splenocytes infected with Encephalomyocarditis virus (EMCV). ...
  • APPLICATION OF AN ACTIVITY-BASED PROBE TO DETERMINE PROTEOLYTIC ACTIVITY OF CELL SURFACE CATHEPSIN G BY MASS CYTOMETRY DATA ACQUISITION 
    Gärtner, Fabian; Knippschild, Uwe; Burster, Timo (ACS Omega, 2020)
    During an immune response, cathepsin G (CatG) takes on the role of adaptive and innate immunity and the outcome depends on the localization of CatG. Soluble, cell surface-bound, or intracellular CatG is also responsible ...
  • Cell surface cathepsin G can be used as an additional marker to distinguish T cell subsets 
    Penczek, Adriane; Burster, Timo (SPANDIDOS, 2019-04)
    The serine protease cathepsin G (CatG) is involved in numerous processes associated with the innate and adaptive immune system. During an immune response, neutrophils secrete CatG, which can bind to the cell surface of ...
  • CONSIDERING THE EXPERIMENTAL USE OF TEMOZOLOMIDE IN GLIOBLASTOMA RESEARCH 
    Herbener, Verena J.; Burster, Timo; Goreth, Alicia; Pruss, Maximilian; Bandemer, Hélène; Baisch, Tim; Fitzel, Rahel; Siegelin, Markus D.; Karpel-Massler, Georg; Debatin, Klaus-Michael; Westhoff, Mike-Andrew; Strobel, Hannah (Biomedicines, 2020-06)
    Temozolomide (TMZ) currently remains the only chemotherapeutic component in the approved treatment scheme for Glioblastoma (GB), the most common primary brain tumour with a dismal patient’s survival prognosis of only ~15 ...
  • INFLUENCE OF OBESITY ON REMODELING OF LUNG TISSUE AND ORGANIZATION OF EXTRACELLULAR MATRIX AFTER BLUNT THORAX TRAUMA 
    Xu, Pengfei; Gärtner, Fabian; Gihring, Adrian; Liu, Congxing; Burster, Timo; Wabitsch, Martin; Knippschild, Uwe; Paschke, Stephan (BMC, 2020-09)
    Background Previously, it has been shown that obesity is a risk factor for recovery, regeneration, and tissue repair after blunt trauma and can affect the rate of muscle recovery and collagen deposition after trauma. To ...
  • NEUTROPHIL ELASTASE AND PROTEINASE 3 CLEAVAGE SITES ARE ADJACENT TO THE POLYBASIC SEQUENCE WITHIN THE PROTEOLYTIC SENSITIVE ACTIVATION LOOP OF THE SARS-COV-2 SPIKE PROTEIN 
    Mustafa, Zhadyra; Zhanapiya, Anuar; Kalbacher, Hubert; Burster, Timo (American Chemical Society Omega, 2021-03-05)
    Serine proteases neutrophil elastase (NE), protease 3 (PR3), cathepsin G (CatG), and neutrophil serine protease 4 (NSP4) are released by activated neutrophils swarming around the place of pathogen invasion to provoke an ...
  • REGULATION OF MHC I MOLECULES IN GLIOBLASTOMA CELLS AND THE SENSITIZING OF NK CELLS 
    Burster, Timo; Gärtner, Fabian; Bulach, Christiane; Zhanapiya, Anuar; Gihring, Adrian; Knippschild, Uwe (Pharmaceuticals, 2021-03-08)
    Immunotherapy has been established as an important area in the therapy of malignant diseases. Immunogenicity sufficient for immune recognition and subsequent elimination can be bypassed by tumors through altered and/or ...
  • REGULATION OF MHC I MOLECULES IN GLIOBLASTOMA CELLS AND THE SENSITIZING OF NK CELLS 
    Burster, Timo; Gärtner, Fabian; Bulach, Christiane; Zhanapiya, Anuar; Gihring, Adrian; Knippschild, Uwe (Pharmaceuticals, 2021-03-08)
    Immunotherapy has been established as an important area in the therapy of malignant diseases. Immunogenicity sufficient for immune recognition and subsequent elimination can be bypassed by tumors through altered and/or ...
  • WHAT ANIMAL CANCERS TEACH US ABOUT HUMAN BIOLOGY 
    Kattner, Patricia; Zeiler, Katharina; Herbener, Verena J.; Ferla-Brühl, Katia La; Kassubek, Rebecca; Grunert, Michael; Burster, Timo; Brühl, Oliver; Weber, Anna Sarah; Strobel, Hannah; Karpel-Massler, Georg; Ott, Sibylle; Hagedorn, Alexa; Tews, Daniel; Schulz, Ansgar; Prasad, Vikas; Siegelin, Markus D.; Nonnenmacher, Lisa; Fischer-Posovszky, Pamela; Halatsch, Marc-Eric; Debatin, Klaus-Michael; Westhoff, Mike-Andrew (Theranostics, 2021)
    Cancers in animals present a large, underutilized reservoir of biomedical information with critical implication for human oncology and medicine in general. Discussing two distinct areas of tumour biology in non-human hosts, ...