DEVELOPMENT OF INTERFEROMETRIC OPTICAL FIBER BIOSENSOR FOR HCC1806 BREAST CANCER CELL DETECTION
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Date
2024-04
Authors
Meirambekuly, Timur
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Nazarbayev University School of Engineering and Digital Sciences
Abstract
This thesis explores the use of semi-distributed interferometric (SDI) optical fiber
biosensors for detecting breast cancer cells, with a focus on assessing the potential and
limitations of this technology. Given the critical importance of early detection in improving
breast cancer outcomes, this research aims to advance diagnostic methodologies by leveraging
the sensitivity and specificity advantages of optical fiber technology, combined with targeted
antibody functionalization.
The study commenced with the fabrication of optical fiber sensors, incorporating
interferometric tips to single-mode optic fiber pigtails. Calibration was performed using
specialized software and equipment, selecting sensors with optimal sensitivity based on their
performance in standardized tests. These sensors were then functionalized with CD44
antibodies, targeting the detection of HCC1806 breast cancer cells across a range of
concentrations. Experimental trials were conducted to evaluate the sensors' ability to detect
cell concentrations from sterilized PBS up to 10^6 cells per ml, with data collection at regular
intervals.
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Type of access: Open access
Citation
Meirambekuly, T. (2024). Development Of Interferometric Optical Fiber Biosensor For Hcc1806 Breast Cancer Cell Detection. Nazarbayev University School of Engineering and Digital Sciences