IMPROVING THE SPECIFICITY AND SENSITIVITY OF OPTICAL SENSORS FOR BIOLOGICAL PURPOSES
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Date
2024-04
Authors
Adilzhankyzy, Aina
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Publisher
Nazarbayev University School of Engineering and Digital Sciences
Abstract
The development of antibody-detecting biosensors using interferometric devices is a
promising area in biomedical engineering. In this study, a semi-distributed interferometer (SDI)
was employed as the biosensor device, utilizing a simplified Fabry-Perot structure. The sensor
was functionalized using a combination of surface functionalization and silanization, with
nanostructuring to enhance the surface area through the application of gold nanorods. The focus
of the research was on the detection of two key biological analytes: the CD44 cancer biomarker
and the A33 glycoprotein of the vaccinia poxvirus. The fabrication and functionalization
processes were optimized for sensitivity and specificity, with the aim of achieving real-time,
label-free detection of these important biomarkers
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Type of access: Restricted
Citation
Adilzhankyzy, A. (2024). Improving The Specificity And Sensitivity Of Optical Sensors For Biological Purposes. Nazarbayev University School of Engineering and Digital Sciences