CELIAC DISEASE AND GALLBLADDER: PATHOPHYSIOLOGICAL ASPECTS AND CLINICAL ISSUES
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Date
2022
Authors
Poddighe, Dimitri
Dossybayeva, Kuanysh
Abdukhakimova, Diyora
Akhmaltdinova, Lyudmila
Ibrayeva, Aigul
Journal Title
Journal ISSN
Volume Title
Publisher
Nutrients
Abstract
Celiac Disease (CD) is an immune-mediated disorder which primarily affects
the small intestine; however, extra-intestinal organs are often affected by the pathological process,
too. As regards the digestive system, liver alterations in CD patients have been widely described,
which can also extend to the biliary tract. Notably, gallbladder function can be altered in CD patients.
In this review, we specifically analyze and summarize the main pathophysiological aspects and
clinical evidence of gallbladder dysfunction in CD patients, in order to discuss the potential medical
complications and clinical research gaps. In addition to some perturbations of bile composition, CD
patients can develop gallbladder dysmotility, which mainly expresses with an impaired emptying
during the digestive phase. The main pathophysiological determinant is a perturbation of cholecystokinin
secretion by the specific duodenal enteroendocrine cells in response to the appropriate
nutrient stimulation in CD patients. This situation appears to be reversible with a gluten-free diet in
most cases. Despite this gallbladder impairment, CD patients do not seem to be more predisposed to
gallbladder complications, such as calculous and acalculous cholecystitis. However, very few clinical
studies have actively investigated these clinical aspects, which may not be completely evidenced so
far; alternatively, the substantial improvements in the last two decades regarding CD diagnosis, which
have reduced the diagnostic delay (and related dietary treatment), may have lessened the potential
clinical consequences of CD-related gallbladder dysfunction. Specific clinical studies focused on these
aspects are needed for a better understanding of the clinical implications of gallbladder alterations in
CD patients.
Description
Keywords
Type of access: Open Access, allbladder, celiac disease, gallbladder dysmotility, cholecystokinin, gluten-free diet, cholecystitis, gallstones
Citation
Poddighe, D., Dossybayeva, K., Abdukhakimova, D., Akhmaltdinova, L., & Ibrayeva, A. (2022). Celiac Disease and Gallbladder: Pathophysiological Aspects and Clinical Issues. Nutrients, 14(20), 4379. https://doi.org/10.3390/nu14204379