CELIAC DISEASE IN JUVENILE IDIOPATHIC ARTHRITIS AND OTHER PEDIATRIC RHEUMATIC DISORDERS
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Date
2022
Authors
Poddighe, Dimitri
Romano, Micol
Dossybayeva, Kuanysh
Abdukhakimova, Diyora
Galiyeva, Dinara
Demirkaya, Erkan
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Clinical Medicine
Abstract
Celiac Disease (CD) is an immune-mediated and gluten-related disorder whose prevalence
is higher in children affected with other autoimmune disorders, including diabetes mellitus type 1,
autoimmune thyroiditis, and others. As regards Juvenile Idiopathic Arthritis (JIA) and other pediatric
rheumatic disorders, there is no clear recommendation for CD serological screening. In this review,
we analyze all the available clinical studies investigating CD among children with JIA (and other
rheumatic diseases), in order to provide objective data to better understand the necessity of CD
serological screening during the follow-up. Based on the present literature review and analysis, >2.5%
patients with JIA were diagnosed with CD; however, the CD prevalence in JIA patients may be even
higher (>3–3.5%) due to several study limitations that could have underestimated CD diagnosis
to a variable extent. Therefore, serological screening for CD in children affected with JIA could
be recommended due to the increased CD prevalence in these patients (compared to the general
pediatric population), and because these JIA patients diagnosed with CD were mostly asymptomatic.
However, further research is needed to establish a cost-effective approach in terms of CD screening
frequency and modalities during the follow-up for JIA patients. Conversely, at the moment, there is
no evidence supporting a periodical CD screening in children affected with other rheumatic diseases
(including pediatric systemic lupus erythematosus, juvenile dermatomyositis, and systemic sclerosis).
Description
Keywords
Type of access: Open Access, celiac disease, juvenile idiopathic arthritis, pediatric systemic lupus erythematosus, juvenile dermatomyositis, systemic scleroderma, screening, prevalence
Citation
Poddighe, D., Romano, M., Dossybayeva, K., Abdukhakimova, D., Galiyeva, D., & Demirkaya, E. (2022). Celiac Disease in Juvenile Idiopathic Arthritis and Other Pediatric Rheumatic Disorders. Journal of Clinical Medicine, 11(4), 1089. https://doi.org/10.3390/jcm11041089