HONGHUA EXTRACT MEDIATED POTENT INHIBITION OF COVID‑19 HOST CELL PATHWAYS
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Date
2022
Authors
Madikyzy, Malika
Tilegen, Meruyert
Nazarbek, Guldan
Mu, Chenglin
Kutzhanova, Aidana
Li, Xugang
Ma, Cuiping
Xie, Yingqiu
Journal Title
Journal ISSN
Volume Title
Publisher
Scientific Reports
Abstract
Honghua (Carthami flos) and Xihonghua (Croci stigma) have been used in anti-COVID-19 as Traditional
Chinese Medicine, but the mechanism is unclear. In this study, we applied network pharmacology
by analysis of active compounds and compound-targets networks, enzyme kinetics assay, signaling
pathway analysis and investigated the potential mechanisms of anti-COVID-19. We found that both
herbs act on signaling including kinases, response to inflammation and virus. Moreover, crocin likely
has an antiviral effect due to its high affinity towards the human ACE2 receptor by simulation. The
extract of Honghua and Xihonghua exhibited nanozyme/herbzyme activity of alkaline phosphatase,
with distinct fluorescence. Thus, our data suggest the great potential of Honghua in the development
of anti-COVID-19 agents.
Description
Keywords
Type of access: Open Access, COVID-19
Citation
Madikyzy, M., Tilegen, M., Nazarbek, G., Mu, C., Kutzhanova, A., Li, X., Ma, C., & Xie, Y. (2022). Honghua extract mediated potent inhibition of COVID-19 host cell pathways. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-15338-9