Browsing 01.NU Schools by Subject "YAP"

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Targeting Mechanotransduction at theTranscriptional Level: YAPandBRD4 Are Novel Therapeutic Targets for the Reversal of Liver Fibrosis

Zhubanchaliyev, Altynbek; Temirbekuly, Aibar; Kongrtay, Kuralay; Wanshura, Leah C.; Kunz, Jeannette (Frontiers in Pharmacology, 2016-12-01)

Liver fibrosis is the result of a deregulated wound healing process characterized by the excessive deposition of extracellular matrix. Hepatic stellate cells (HSCs), which are activated in response to liver injury, are the ...
YAP MEDIATES HAIR CELL REGENERATION IN BALANCE ORGANS OF CHICKENS, BUT LATS KINASES SUPPRESS ITS ACTIVITY IN MICE

Rudolf, Mark A.; Andreeva, Anna; Kozlowski, Mikolaj M.; Kim, Christina E.; Moskowitz, Bailey A.; Anaya-Rocha, Alejandro; Kelley, Matthew W.; Corwin, Jeffrey T. (Society for Neuroscience, 2020-05-13)

Loss of sensory hair cells causes permanent hearing and balance deficits in humans and other mammals, but for nonmammals such deficits are temporary. Nonmammals recover hearing and balance sensitivity after supporting cells ...