REVIEW OF COVID-19 TESTING AND DIAGNOSTIC METHODS
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Date
2022
Authors
Filchakova, Olena
Dossym, Dina
Ilyas, Aisha
Kuanysheva, Tamila
Abdizhamil, Altynay
Bukasov, Rostislav
Journal Title
Journal ISSN
Volume Title
Publisher
Talanta
Abstract
More than six billion tests for COVID-19 has been already performed in the world. The testing for SARS-CoV-2
(Severe Acute Respiratory Syndrome Coronavirus-2) virus and corresponding human antibodies is essential not
only for diagnostics and treatment of the infection by medical institutions, but also as a pre-requisite for major
semi-normal economic and social activities such as international flights, off line work and study in offices, access
to malls, sport and social events. Accuracy, sensitivity, specificity, time to results and cost per test are essential
parameters of those tests and even minimal improvement in any of them may have noticeable impact on life in
the many countries of the world. We described, analyzed and compared methods of COVID-19 detection, while
representing their parameters in 22 tables. Also, we compared test performance of some FDA approved test kits
with clinical performance of some non-FDA approved methods just described in scientific literature. RT-PCR still
remains a golden standard in detection of the virus, but a pressing need for alternative less expensive, more
rapid, point of care methods is evident. Those methods that may eventually get developed to satisfy this need are
explained, discussed, quantitatively compared. The review has a bioanalytical chemistry prospective, but it may
be interesting for a broader circle of readers who are interested in understanding and improvement of COVID-19
testing, helping eventually to leave COVID-19 pandemic in the past.
Description
Keywords
Type of access: Open Access, COVID-19 tests, SARS CoV-2, Antibody to SARS-CoV-2, RT-PCR of SARS CoV-2, CRISPR, LAMP, ELISA, CLIA, Lateral flow immunoassays, Rapid detection, CT scanning, Ultrasound scanning, Time to results, False positive results, False negative results
Citation
Filchakova, O., Dossym, D., Ilyas, A., Kuanysheva, T., Abdizhamil, A., & Bukasov, R. (2022). Review of COVID-19 testing and diagnostic methods. Talanta, 244, 123409. https://doi.org/10.1016/j.talanta.2022.123409