HLA-binding peptide affinity prediction and T cell-mediated response
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Date
2013
Authors
Schönbach, C.
Su, C.
Kwoh, C-K.
Journal Title
Journal ISSN
Volume Title
Publisher
Nazarbayev University
Abstract
In a future pandemic it is therefore expected that apart from a few mutated epitopes, heterologous immunity mediated by pre-existing cross-reactive T cell responses to seasonal influenza virus will ameliorate its severity and extent. While it is possible to successfully infer potential differences in recognition and cross-reactivity for a few alleles, here HLA-B*4405, an extension to population level is limited. The bottom line in in silico inference of epitope candidates that may induce a broad T cell response is data.
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Keywords
first research week, human leukocyte antigen, innovative scientific research