Association of vitamin D receptor (FOKI, TAQI, APAI & BSMI) and IF-y genes' polymorphisms with risk of developing pulmonary TB (PTB) among Kazakhstani population
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Date
2014
Authors
Yerezhepov, D.
Zhabagin, M.
Abilova, Zh.
Askapuli, A.
Abilmazhinova, A.
Rakhimova, S.
Kairov, U.
Molkenov, A.
Akhmetova, A.
Akilzhanova, A.
Journal Title
Journal ISSN
Volume Title
Publisher
Nazarbayev University
Abstract
Almost one third of the world's population is infected with Mycobacterium tuberculosis
(MTB) and only 10% of them will develop any active form of the disease. TB is second (1s t is HIV/AIDS)
greatest killer worldwide due to a single infectious agent. In 2012, 8.6 million people developed active TB
and 1.3 million died. Over 95% of TB deaths occur in developing countries. In 2012, an estimated more
than half million children became ill with TB and 74 000 of them died. The TB cases are declining annually,
but very slowly. Multi-drug resistant TB (MDR-TB) and extensively drug-resistant tuberculosis (XDRTB)
is present in almost all surveyed countries. Kazakhstan is not highly burdened by TB. Kazakhstan is
the list of MDR-TB and XDR-TB burden countries. Our aim is to investigate an association of Vitamin D
receptor (FokI, TaqI, ApaI & BsmI) and IF-y genes" polymorphisms with risk of developing pulmonary
TB (PTB) among Kazakhstani population.
Description
Keywords
vitamin D, FokI, TaqI, ApaI, BsmI, IF-y genes, polymorphisms, pulmonary, healthy